Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Springer full text link Springer
Full text links

Actions

Share

.2024 Oct;39(7):1363-1385.
doi: 10.1007/s11011-024-01391-y. Epub 2024 Aug 8.

Assessment of the potential protective effects of culture filtrate of Trichoderma harzianum to ameliorate the damaged histoarchitecture of brain in epileptic rats

Affiliations

Assessment of the potential protective effects of culture filtrate of Trichoderma harzianum to ameliorate the damaged histoarchitecture of brain in epileptic rats

Sally M A El-Shafei et al. Metab Brain Dis.2024 Oct.

Abstract

The simultaneous hyperexcitability of the neural network is the most well-known manifestation of epilepsy that causes recurrent seizures. The current study was aimed to examine any potential safety benefits of the culture filtrate of Trichoderma harzianum (ThCF) to ameliorate damaged histoarchitecture of the brain in epileptic rats by assessing seizure intensity scale and behavioral impairments and follow up the spontaneous motor seizures during status epilepticus phases in rats. Twenty-four rats were divided into four groups; control (C), epileptic (EP) valproic acid-treated epileptic (EP-VPA), and epileptic treated with T. harzianum cultured filtrate (ThCF). In addition to a seizure intensity score and behavioral tests, routine H&E and Golgi-Copsch histopathology, were used to examine the cell somas, dendrites, axons, and neural spines. ThCF treatment increased activity and recorded movements during grooming, rearing, and ambulation frequency. Brain tissues of epileptic rats exhibited detached meninges, hypercellularity, mild edema in the cortex and markedly degenerated neurons, degenerated glial cells, and microcyst formation in the hippocampus. Moreover, brains of EP-ThCF were noticed with average blood vessels, and increased dendritogenesis. The current data revealed some of negative effects of epileptogenesis brought on by seizure intensity score and retarded histopathological alterations in the hippocampus. Therefore, the study is forecasting to identify novel active components from the metabolites of T. harzianum with a crucial therapeutic role in various disorders.

Keywords: Trichoderma harzianum; Epilepsy; H&E-Golgi-copsch stain; Hippocampus.

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Abd El-Hameed AM, Abuelsaad ASA, Khalil A (2021) Bee venom acupuncture therapy ameliorates neuroinflammatory alterations in a pilocarpine-induced epilepticus model. Metab Brain Dis 36(7):2047–2058 - PubMed - DOI
    1. Abd El-Rahman AAE-M, Abd El-Aziz ElShafei SM, Ivanova EV, Fattakhova AN, Pankova AV, El-Shafei MAE-A, ... Alimova FK (2014) Cytotoxicity of Trichoderma spp. cultural filtrate against human cervical and breast cancer cell lines. Asian Pac J Cancer Prev 15(17):7229–7234
    1. Abd El-Rahman AA, El-Shafei SM, Shehab GM, Mansour L, Abuelsaad AS, Gad RA (2023) Assessment of biochemical and neuroactivities of cultural filtrate from Trichoderma harzianum in adjusting electrolytes and neurotransmitters in Hippocampus of epileptic rats. Life 13(9):1815 - PubMed - PMC - DOI
    1. Abdel-Latif RG, Heeba GH, Taye A, Khalifa M (2018) Lixisenatide, a novel GLP-1 analog, protects against cerebral ischemia/reperfusion injury in diabetic rats. Naunyn Schmiedebergs Arch Pharmacol 391(7):705–717 - PubMed - DOI
    1. Abdel-Reheim ES (2009) Physiological and biochemical studies on the melatonin effect on the fertility of epileptic rats. J Egyp Ger Soci Zool 58:1–25

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full text links
Springer full text link Springer
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp