Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Frontiers Media SA full text link Frontiers Media SA Free PMC article
Full text links

Actions

Share

.2024 Jul 10:11:1341963.
doi: 10.3389/fnut.2024.1341963. eCollection 2024.

Oral nutritional supplementation with dietary counseling improves linear catch-up growth and health outcomes in children with or at risk of undernutrition: a randomized controlled trial

Affiliations

Oral nutritional supplementation with dietary counseling improves linear catch-up growth and health outcomes in children with or at risk of undernutrition: a randomized controlled trial

Mandy Y L Ow et al. Front Nutr..

Abstract

Introduction: Childhood undernutrition is associated with increased morbidity, mortality and a high socio-economic burden.

Methods:SupportingPediatric GRowth and HealthOUTcomes (SPROUT) is a randomized, controlled trial evaluating the effects of an oral nutritional supplement (ONS) with dietary counseling (DC;n = 164) compared to a DC-only group who continued consuming their habitual milk (n = 166;NCT05239208). Children aged 24-60 months who were at risk or with undernutrition, as defined by weight-for-age [WAZ] < -1 and height-for-age [HAZ] < -1 according to the WHO Growth Standards, and who also met the criterion of weight-for-height [WHZ] < 0, were enrolled in Vietnam.

Results: ONS + DC had a larger WAZ increase at day 120 (primary endpoint) vs. DC (least squares mean, LSM (SE): 0.30 (0.02) vs. 0.13 (0.02);p < 0.001), and larger improvements in all weight, BMI and weight-for-height indices at day 30 and 120 (allp < 0.01). Height gain was larger in ONS + DC in all indices, including height-for-age difference [HAD; cm: 0.56 (0.07) vs. 0.10 (0.07);p < 0.001], at day 120. ONS + DC had larger arm muscle but not arm fat indices, higher parent-rated appetite, physical activity and energy levels, longer night sleep, fewer and shorter awakenings, and better sleep quality than DC.

Conclusion: Adding ONS to DC, compared to DC-alone, improves growth in weight and height, linear catch-up growth, and health outcomes in children with or at risk of undernutrition.

Keywords: catch-up growth; children; oral nutritional supplements; physical activity; sleep; stunting; undernutrition; underweight.

Copyright © 2024 Ow, Tran, Berde, Nguyen, Tran, Jablonka, Baggs and Huynh.

PubMed Disclaimer

Conflict of interest statement

MO, MJ, GB, and DH were employees of Abbott Nutrition. Abott Nutrition is the sponsor of the study. YB was an employee of Cognizant Technology Solutions. Cognizant Technology Solutions is responsible for statistical data analyses, at the time of study conduct, analysis and manuscript preparation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
CONSORT study flow diagram. DC, dietary counseling; ITT, intention-to-treat; ONS, oral nutritional supplements; PP, per-protocol.
Figure 2
Figure 2
Severity of underweight, stunting, and wasting of the overall study population at baseline. Severity of undernutrition is defined by z-score cut-offs as: ≥ −1 for normal/no undernutrition;< −1 to ≥ −2 for mild;< −2 to ≥ −3 for moderate; and < −3 for severe undernutrition, using weight-for-age, height-for-age, and weight-for-height indices for underweight, stunting and wasting, respectively.
Figure 3
Figure 3
Anthropometric indices at baseline, day 30, and day 120 by treatment group for(A) WAZ,(B) HAZ,(C) WHZ, and(D) WHZ by baseline WHZ status. Baseline values were ANOVA LSM ± SE and day 30 and 120 values were from repeated-measures ANCOVA estimates. *indicatesp < 0.05 for between-group comparisons with ANCOVA for that timepoint. CI, confidence interval; HAZ, height-for-age-z score; LSM, least squares mean; SE, standard error; WAZ, weight-for-age z score; WHZ, weight-for-height-z score.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, et al. . Maternal and child undernutrition study group. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet. (2008) 371:243–60. doi: 10.1016/S0140-6736(07)61690-0 - DOI - PubMed
    1. United Nations Children's Fund, World Health Organization, World Bank Group . Levels and trends in child malnutrition: UNICEF/WHO/the World Bank Group joint child malnutrition estimates: Key findings of the 2021 edition. Geneva: World Health Organization (2021).
    1. Becker PJ, Carney LN, Corkins MR, Monczka J, Smith E, Smith SE, et al. . Consensus statement of the academy of nutrition and dietetics/American Society for Parenteral and Enteral Nutrition: indicators recommended for the identification and documentation of pediatric malnutrition (undernutrition). J Acad Nutr Diet. (2014) 114:1988–2000. doi: 10.1016/j.jand.2014.08.026, PMID: - DOI - PubMed
    1. World Health Organization . Physical status: The use of and interpretation of anthropometry, report of a WHO expert committee. Geneva: World Health Organization (1995). - PubMed
    1. Nguyen PH, Menon P, Ruel M. A situational review of infant and young child feeding practices and interventions in Viet Nam. Asia Pac J Clin Nutr. (2011) 20:359–74. PMID: - PubMed

Related information

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by Abbott Nutrition.

LinkOut - more resources

Full text links
Frontiers Media SA full text link Frontiers Media SA Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp