Review

.2024 Aug;20(6):1459-1479.

doi: 10.1007/s12015-024-10740-4. Epub 2024 May 29.

Towards Stem/Progenitor Cell-Based Therapies for Retinal Degeneration

Hui Liu^#^{1 2}, Shuaiyan Lu^#^{1 2}, Ming Chen^{1 2}, Na Gao^{1 2}, Yuhe Yang^{1 2}, Huijuan Hu^{1 2}, Qing Ren^{1 2}, Xiaoyu Liu^{1 2}, Hongxu Chen^{1 2}, Qunyan Zhu³, Shasha Li^{4 5 6}, Jianzhong Su^{7 8 9 10}

Affiliations

¹ National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
² State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
³ Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325011, China.
⁴ National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. lishasha@ojlab.ac.cn.
⁵ State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. lishasha@ojlab.ac.cn.
⁶ Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325001, China. lishasha@ojlab.ac.cn.
⁷ National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. sujz@wmu.edu.cn.
⁸ State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. sujz@wmu.edu.cn.
⁹ Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325011, China. sujz@wmu.edu.cn.
¹⁰ Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325001, China. sujz@wmu.edu.cn.

^# Contributed equally.

PMID:38809490
DOI: 10.1007/s12015-024-10740-4

Review

Towards Stem/Progenitor Cell-Based Therapies for Retinal Degeneration

Hui Liu et al. Stem Cell Rev Rep.2024 Aug.

.2024 Aug;20(6):1459-1479.

doi: 10.1007/s12015-024-10740-4. Epub 2024 May 29.

Authors

Affiliations

¹ National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
² State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
³ Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325011, China.
⁴ National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. lishasha@ojlab.ac.cn.
⁵ State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. lishasha@ojlab.ac.cn.
⁶ Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325001, China. lishasha@ojlab.ac.cn.
⁷ National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. sujz@wmu.edu.cn.
⁸ State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. sujz@wmu.edu.cn.
⁹ Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325011, China. sujz@wmu.edu.cn.
¹⁰ Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325001, China. sujz@wmu.edu.cn.

^# Contributed equally.

PMID:38809490
DOI: 10.1007/s12015-024-10740-4

Abstract

Retinal degeneration (RD) is a leading cause of blindness worldwide and includes conditions such as retinitis pigmentosa (RP), age-related macular degeneration (AMD), and Stargardt's disease (STGD). These diseases result in the permanent loss of vision due to the progressive and irreversible degeneration of retinal cells, including photoreceptors (PR) and the retinal pigment epithelium (RPE). The adult human retina has limited abilities to regenerate and repair itself, making it challenging to achieve complete self-replenishment and functional repair of retinal cells. Currently, there is no effective clinical treatment for RD. Stem cell therapy, which involves transplanting exogenous stem cells such as retinal progenitor cells (RPCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs), or activating endogenous stem cells like Müller Glia (MG) cells, holds great promise for regenerating and repairing retinal cells in the treatment of RD. Several preclinical and clinical studies have shown the potential of stem cell-based therapies for RD. However, the clinical translation of these therapies for the reconstruction of substantial vision still faces significant challenges. This review provides a comprehensive overview of stem/progenitor cell-based therapy strategies for RD, summarizes recent advances in preclinical studies and clinical trials, and highlights the major challenges in using stem/progenitor cell-based therapies for RD.

Keywords: Clinical trials; Regeneration; Retinal cells; Retinal degeneration; Stem cell therapy; Transplantation.

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References

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Towards Stem/Progenitor Cell-Based Therapies for Retinal Degeneration

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Towards Stem/Progenitor Cell-Based Therapies for Retinal Degeneration

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