Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder
- PMID:38672454
- PMCID: PMC11048423
- DOI: 10.3390/biom14040437
Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by severe deficits in social communication and interaction, repetitive movements, abnormal focusing on objects, or activity that can significantly affect the quality of life of the afflicted. Neuronal and glial cells have been implicated. It has a genetic component but can also be triggered by environmental factors or drugs. For example, prenatal exposure to valproic acid or acetaminophen, or ingestion of propionic acid, can increase the risk of ASD. Recently, epigenetic influences on ASD have come to the forefront of investigations on the etiology, prevention, and treatment of this disorder. Epigenetics refers to DNA modifications that alter gene expression without making any changes to the DNA sequence. Although an increasing number of pharmaceuticals and environmental chemicals are being implicated in the etiology of ASD, here, we specifically focus on the molecular influences of the abovementioned chemicals on epigenetic alterations in neuronal and glial cells and their potential connection to ASD. We conclude that a better understanding of these phenomena can lead to more effective interventions in ASD.
Keywords: acetaminophen; autism spectrum disorder; epigenetics; gliosis; neuroinflammation; propionic acid; teratogen; valproic acid.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Similar articles
- Depressing time: Waiting, melancholia, and the psychoanalytic practice of care.Salisbury L, Baraitser L.Salisbury L, et al.In: Kirtsoglou E, Simpson B, editors. The Time of Anthropology: Studies of Contemporary Chronopolitics. Abingdon: Routledge; 2020. Chapter 5.In: Kirtsoglou E, Simpson B, editors. The Time of Anthropology: Studies of Contemporary Chronopolitics. Abingdon: Routledge; 2020. Chapter 5.PMID:36137063Free Books & Documents.Review.
- "I've Spent My Whole Life Striving to Be Normal": Internalized Stigma and Perceived Impact of Diagnosis in Autistic Adults.Huang Y, Trollor JN, Foley KR, Arnold SRC.Huang Y, et al.Autism Adulthood. 2023 Dec 1;5(4):423-436. doi: 10.1089/aut.2022.0066. Epub 2023 Dec 12.Autism Adulthood. 2023.PMID:38116050Free PMC article.
- Australia in 2030: what is our path to health for all?Backholer K, Baum F, Finlay SM, Friel S, Giles-Corti B, Jones A, Patrick R, Shill J, Townsend B, Armstrong F, Baker P, Bowen K, Browne J, Büsst C, Butt A, Canuto K, Canuto K, Capon A, Corben K, Daube M, Goldfeld S, Grenfell R, Gunn L, Harris P, Horton K, Keane L, Lacy-Nichols J, Lo SN, Lovett RW, Lowe M, Martin JE, Neal N, Peeters A, Pettman T, Thoms A, Thow AMT, Timperio A, Williams C, Wright A, Zapata-Diomedi B, Demaio S.Backholer K, et al.Med J Aust. 2021 May;214 Suppl 8:S5-S40. doi: 10.5694/mja2.51020.Med J Aust. 2021.PMID:33934362
- Qualitative evidence synthesis informing our understanding of people's perceptions and experiences of targeted digital communication.Ryan R, Hill S.Ryan R, et al.Cochrane Database Syst Rev. 2019 Oct 23;10(10):ED000141. doi: 10.1002/14651858.ED000141.Cochrane Database Syst Rev. 2019.PMID:31643081Free PMC article.
- The effectiveness of abstinence-based and harm reduction-based interventions in reducing problematic substance use in adults who are experiencing homelessness in high income countries: A systematic review and meta-analysis: A systematic review.O'Leary C, Ralphs R, Stevenson J, Smith A, Harrison J, Kiss Z, Armitage H.O'Leary C, et al.Campbell Syst Rev. 2024 Apr 21;20(2):e1396. doi: 10.1002/cl2.1396. eCollection 2024 Jun.Campbell Syst Rev. 2024.PMID:38645303Free PMC article.Review.
References
- Maenner M.J., Warren Z., Williams A.R., Amoakohene E., Bakian A.V., Bilder D.A., Durkin M.S., Fitzgerald R.T., Furnier S.M., Hughes M.M., et al. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years—Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020. MMWR Surveill. Summ. 2023;72:1–14. doi: 10.15585/mmwr.ss7202a1. - DOI - PMC - PubMed
- Masini E., Loi E., Vega-Benedetti A.F., Carta M., Doneddu G., Fadda R., Zavattari P. An Overview of the Main Genetic, Epigenetic and Environmental Factors Involved in Autism Spectrum Disorder Focusing on Synaptic Activity. Int. J. Mol. Sci. 2020;21:8290. doi: 10.3390/ijms21218290. - DOI - PMC - PubMed
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Medical