Redirection Notice
Treatment of ocular rosacea: a systematic review
- PMID:38243868
- DOI: 10.1111/ddg.15290
Treatment of ocular rosacea: a systematic review
Abstract
Rosacea is a common chronic skin disease distributed primarily around the central face. Ocular manifestations of rosacea are poorly studied, and estimates of prevalence vary widely, ranging from 6% to 72% in the rosacea population. Treatment options for ocular rosacea include lid hygiene, topical and oral antibiotics, cyclosporine ophthalmic emulsion, oral vitamin A derivatives, and intense pulsed light; however, a direct comparison of treatment methods for ocular rosacea is lacking. This review aims to compare treatment efficacy and adverse events for different treatment modalities in ocular rosacea. We performed a systematic review by searching Cochrane, MEDLINE and Embase. Title, abstract, full text screening, and data extraction were done in duplicate. Sixty-six articles met the inclusion criteria, representing a total of 1,275 patients. The most effective treatment modalities were topical antimicrobials and oral antibiotics, which achieved complete or partial response in 91% (n = 82/90) and 89% (n = 525/580) of patients respectively, followed by intense pulsed light (89%, n = 97/109 partial response), cyclosporine ophthalmic emulsion (87% n = 40/46), and lid hygiene (65%, n = 67/105). Combination treatments achieved a complete or partial response in 90% (n = 69/77). Results suggest that topical antimicrobials, oral antibiotics, intense pulsed light. and cyclosporine were the most efficacious single modality treatments.
Keywords: IPL; Rosacea; adverse events; doxycycline; isotretinoin; ocular; treatment.
© 2024 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.
Similar articles
- Interventions for rosacea.van Zuuren EJ, Fedorowicz Z, Carter B, van der Linden MM, Charland L.van Zuuren EJ, et al.Cochrane Database Syst Rev. 2015 Apr 28;2015(4):CD003262. doi: 10.1002/14651858.CD003262.pub5.Cochrane Database Syst Rev. 2015.PMID:25919144Free PMC article.Review.
- Treatment of pediatric ocular rosacea: A systematic review.Khaslavsky S, Starkey SY, Avraham S, Kashetsky N, Mukovozov I.Khaslavsky S, et al.Ann Dermatol Venereol. 2023 Sep;150(3):199-201. doi: 10.1016/j.annder.2023.05.004. Epub 2023 Aug 16.Ann Dermatol Venereol. 2023.PMID:37596128
- Interventions for rosacea.van Zuuren EJ, Kramer S, Carter B, Graber MA, Fedorowicz Z.van Zuuren EJ, et al.Cochrane Database Syst Rev. 2011 Mar 16;(3):CD003262. doi: 10.1002/14651858.CD003262.pub4.Cochrane Database Syst Rev. 2011.Update in:Cochrane Database Syst Rev. 2015 Apr 28;(4):CD003262. doi: 10.1002/14651858.CD003262.pub5.PMID:21412882Updated.Review.
- Effects of combined oral doxycycline and topical cyclosporine treatment on ocular signs, symptoms, and tear film parameters in rosacea patients.Bilgin B, Karadag AS.Bilgin B, et al.Arq Bras Oftalmol. 2018 Nov./Dec.;81(6):466-470. doi: 10.5935/0004-2749.20180093. Epub 2018 Oct 8.Arq Bras Oftalmol. 2018.PMID:30304088
- Interventions for rosacea based on the phenotype approach: an updated systematic review including GRADE assessments.van Zuuren EJ, Fedorowicz Z, Tan J, van der Linden MMD, Arents BWM, Carter B, Charland L.van Zuuren EJ, et al.Br J Dermatol. 2019 Jul;181(1):65-79. doi: 10.1111/bjd.17590. Epub 2019 Mar 10.Br J Dermatol. 2019.PMID:30585305Free PMC article.
Cited by
- Rosacea is strongly associated with melanoma in Caucasians.von Stebut J, Mallach M, Schneider-Burrus S, Heiland M, Rendenbach C, Preissner R, Preissner S.von Stebut J, et al.Sci Rep. 2024 May 25;14(1):11949. doi: 10.1038/s41598-024-62552-8.Sci Rep. 2024.PMID:38789467Free PMC article.
References
REFERENCES
- Gallo RL, Granstein RD, Kang S, et al. Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee. J Am Acad Dermatol. 2018;78(1):148-155.
- Tidman MJ. Improving the management of rosacea in primary care. Practitioner. 2014;258(1775):3,27-30.
- Arman A, Demirseren DD, Takmaz T. Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline. Int J Ophthalmol. 2015;8(3):544-549.
- Wladis EJ, Adam AP. Treatment of ocular rosacea. Surv Ophthalmol. 2018;63(3):340-346.
- Tanzi EL, Weinberg JM. The ocular manifestations of rosacea. Cutis. 2001;68(2):112-114.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous