Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Elsevier Science full text link Elsevier Science
Full text links

Actions

Share

.1986 Sep;7(3):177-88.
doi: 10.1016/0197-2456(86)90046-2.

Meta-analysis in clinical trials

Free article

Meta-analysis in clinical trials

R DerSimonian et al. Control Clin Trials.1986 Sep.
Free article

Abstract

This paper examines eight published reviews each reporting results from several related trials. Each review pools the results from the relevant trials in order to evaluate the efficacy of a certain treatment for a specified medical condition. These reviews lack consistent assessment of homogeneity of treatment effect before pooling. We discuss a random effects approach to combining evidence from a series of experiments comparing two treatments. This approach incorporates the heterogeneity of effects in the analysis of the overall treatment efficacy. The model can be extended to include relevant covariates which would reduce the heterogeneity and allow for more specific therapeutic recommendations. We suggest a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.

PubMed Disclaimer

Comment in

Similar articles

  • The future of Cochrane Neonatal.
    Soll RF, Ovelman C, McGuire W.Soll RF, et al.Early Hum Dev. 2020 Nov;150:105191. doi: 10.1016/j.earlhumdev.2020.105191. Epub 2020 Sep 12.Early Hum Dev. 2020.PMID:33036834
  • Meta-analysis in clinical trials revisited.
    DerSimonian R, Laird N.DerSimonian R, et al.Contemp Clin Trials. 2015 Nov;45(Pt A):139-45. doi: 10.1016/j.cct.2015.09.002. Epub 2015 Sep 4.Contemp Clin Trials. 2015.PMID:26343745Free PMC article.
  • Patient heterogeneity in clinical trials.
    Simon R.Simon R.Cancer Treat Rep. 1980 Feb-Mar;64(2-3):405-10.Cancer Treat Rep. 1980.PMID:7407777
  • Ablation: Atrial fibrillation: diagnosis and management: Network meta-analysis J2.
    National Guideline Centre (UK).National Guideline Centre (UK).London: National Institute for Health and Care Excellence (NICE); 2021 Apr.London: National Institute for Health and Care Excellence (NICE); 2021 Apr.PMID:34165931Free Books & Documents.Review.
  • Palliative Treatment of Cancer-Related Pain [Internet].
    Kongsgaard U, Kaasa S, Dale O, Ottesen S, Nordøy T, Hessling SE, von Hofacker S, Bruland ØS, Lyngstadaas A.Kongsgaard U, et al.Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2005 Dec. Report from Norwegian Knowledge Centre for the Health Services (NOKC) No. 09-2005.Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2005 Dec. Report from Norwegian Knowledge Centre for the Health Services (NOKC) No. 09-2005.PMID:29320015Free Books & Documents.Review.
See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full text links
Elsevier Science full text link Elsevier Science
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp