Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Silverchair Information Systems full text link Silverchair Information Systems Free PMC article
Full text links

Actions

Share

.2023 Dec 9;33(24):11623-11633.
doi: 10.1093/cercor/bhad396.

Brain asymmetry is globally different in males and females: exploring cortical volume, area, thickness, and mean curvature

Affiliations

Brain asymmetry is globally different in males and females: exploring cortical volume, area, thickness, and mean curvature

Magda L Dumitru. Cereb Cortex..

Abstract

Brain asymmetry is a cornerstone in the development of higher-level cognition, but it is unclear whether and how it differs in males and females. Asymmetry has been investigated using the laterality index, which compares homologous regions as pairwise weighted differences between the left and the right hemisphere. However, if asymmetry differences between males and females are global instead of pairwise, involving proportions between multiple brain areas, novel methodological tools are needed to evaluate them. Here, we used the Amsterdam Open MRI collection to investigate sexual dimorphism in brain asymmetry by comparing laterality index with the distance index, which is a global measure of differences within and across hemispheres, and with the subtraction index, which compares pairwise raw values in the left and right hemisphere. Machine learning models, robustness tests, and group analyses of cortical volume, area, thickness, and mean curvature revealed that, of the three indices, distance index was the most successful biomarker of sexual dimorphism. These findings suggest that left-right asymmetry in males and females involves global coherence rather than pairwise contrasts. Further studies are needed to investigate the biological basis of local and global asymmetry based on growth patterns under genetic, hormonal, and environmental factors.

Keywords: brain asymmetry; coherence; distance index; laterality; sexual dimorphism.

© The Author(s) 2023. Published by Oxford University Press.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Performance of binary classification models. Each 2 × 2 confusion matrix corresponds to a specific measure (volume, area, thickness, or curvature) and index (DI, LI, or SI) with accuracy,p-value relative to no-information rate, andCohen's Kappa given underneath. True positive, false positive, false negative, and true negative quadrants in each matrix include overall percentage and count in the middle. Column percentages are given at the bottom and row percentages to the right in each quadrant. Six regions of interest are displayed on lateral and medial cortical maps, ranking from most important (lightest) to least important (darkest) for each model.
Fig. 2
Fig. 2
Image-quality metrics and their impact on asymmetry indices DI, LI, and SI. Average metric values (CJV, CNR, EFC, INU, and WM2MAX) are given for males and females in the full sample (all 826 right-handed participants) and in two subsamples corresponding to upper and lower metric levels (A). Average index values corresponding to upper and lower image-quality levels are given for males and females for cortical measures—volume, area, thickness, and curvature (B). Significance levels oft-tests between males and females are marked as “*” if less than 0.001, as “x” if less than 0.05 but higher than 0.001, and as “ns” if higher than 0.05. Note that SI scores are all “ns.”
Fig. 3
Fig. 3
Group analyses and correlations of males/females with index values. Pearson correlation coefficients are given for sex versus raw values in the left and right hemisphere over aggregated regions of interest for all cortical measures—volume, area, thickness, and curvature (A). Significance levels of pairedt-tests between male and female index values for cortical measures are marked as “*,” “x,” and “ns” if less than 0.001, less than 0.05 but higher than 0.001, and higher than 0.05, respectively (B). Pearson correlation coefficients for sex versus each asymmetry index across cortical measures (C).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Atkinson D, Hill DL, Stoyle PN, Summers PE, Keevil SF. Automatic correction of motion artifacts in magnetic resonance images using an entropy focus criterion. IEEE Trans Med Imaging. 1997:16(6):903–910. - PubMed
    1. Avants BB, Epstein CL, Grossman M, Gee JC. Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain. Med Image Anal. 2008:12(1):26–41. - PMC - PubMed
    1. Bilder RM, Wu H, Bogerts B, Degreef G, Ashtari M, Alvir JM, Snyder PJ, Lieberman JA. Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. Am J Psychiatry. 1994:151(10):1437–1447. - PubMed
    1. Boersma B, Wit JM. Catch-up growth. Endocr Rev. 1997:18(5):646–661. - PubMed
    1. Breiman L. Random Forests. Mach Learn. 2001:45(1):5–32.

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full text links
Silverchair Information Systems full text link Silverchair Information Systems Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp