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.2022 Nov 2;17(11):e0275823.
doi: 10.1371/journal.pone.0275823. eCollection 2022.

Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials

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Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials

Abigail A Marsh et al. PLoS One..

Abstract

In human challenge trials (HCTs), volunteers are deliberately infected with an infectious agent. Such trials can be used to accelerate vaccine development and answer important scientific questions. Starting early in the COVID-19 pandemic, ethical concerns were raised about using HCTs to accelerate development and approval of a vaccine. Some of those concerns pertained to potential exploitation of and/or lack of truly informed consent from volunteers. Specific areas of concern arose around individuals who may be unusually risk-seeking or too economically vulnerable to refuse the payments these trials provide, as opposed to being motivated primarily by altruistic goals. This pre-registered study is the first large-scale survey to characterize people who, early in the pandemic, expressed interest and intention to volunteer to participate in COVID-19 HCTs. We found that individuals expressing interest in SARS-CoV-2 HCTs exhibit consistently altruistic motivations without any special indication of poor risk perception or economic vulnerability. In finding that, early in the pandemic, COVID-19 HCTs were able to attract volunteers whose values align with the nature of these trials, and who are not unusually vulnerable to exploitation, this study may allay some ethical concerns about the volunteers interested in participating in such trials.

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Conflict of interest statement

The authors have read the journal’s policy and have the following competing interests: SMR and VS were employees of 1Day Sooner at the time of this study. JM is a current employee of 1Day Sooner. NE and AAM are on the Board of Advisors for 1Day Sooner. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.

Figures

Fig 1
Fig 1. CONSORT diagram of volunteer and control group enrollment and analysis.
9,976 volunteers from the 1Day Sooner database who had indicated they were interested in contributing to further research were contacted to participate in this study. Of these, 7,486 volunteers did not reply or declined to participate. The remaining 2,490 volunteers completed the survey via the Qualtrics platform (25% response rate). 579 of these responses were ultimately excluded from the final analysis due to failure to complete sufficient portions of the survey, missing data, or submitting a birth date that indicated they were under 18 years of age. The remaining 1,911 responses were analyzed for inclusion in this report.
Fig 2
Fig 2. Volunteer group motivations for participating in human challenge studies and comparison of engagement in altruistic behaviors by volunteer vs. control group.
(A) Participants in the volunteer group were asked to indicate their top three motivations for participating in a COVID-19 challenge trial from a list of ten options. Selections were not ranked, and total percentages add to 300% because each participant selected 3 options. The two most commonly selected options were “I wanted to help others and potentially save lives” (95.9%) and “I wanted to contribute to the progress of medicine” (79.2%). (B) Participants in volunteer and control groups were surveyed on their engagement with a range of altruistic behaviors, including blood donation, significant charitable donations and organ/marrow donor status. Volunteers were significantly more likely than controls to have participated in all but one of the altruistic behaviors.
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References

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This study was supported by 1Day Sooner in the form of a grant as part of the Open Philanthropy Project, and in the form of salaries for authors SMR, VS, & JM. This study was also supported by 1Day Sooner in the form of additional financial support for MP. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported by National Science Foundation in the form of grants for MM, NE (2039320) and AAM (1729406). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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