doi: 10.15227/orgsyn.097.0327. Epub 2020 Nov 6.
Asymmetric Michael Addition of Dimethyl Malonate to 2-Cyclopenten-1-one Catalyzed by a Heterobimetallic Complex
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- PMID:35614904
- PMCID: PMC9128456
- DOI: 10.15227/orgsyn.097.0327
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Asymmetric Michael Addition of Dimethyl Malonate to 2-Cyclopenten-1-one Catalyzed by a Heterobimetallic Complex
Nicholas J Fastuca et al. Organic Synth.2020.
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Abstract
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A. Cannula transfer of sodiumtert-butoxide solution to(S)-BINOL solution; B. Cannula transfer of sodiumtert-butoxide and(S)-BINOL solution to gallium (III) chloride solution; C. Reaction to form (S)-2 before being allowed to settle; D. Catalyst solution after settling (photo provided by submitters, who used one-necked flasks and non-metal cannula)
Reaction setup for Step B (photo provided by checker)
Short path distillation setup with water condenser to cool condensate (photo provided by checker)
References
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