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Randomized Controlled Trial
.2022 Jan 28;19(3):1480.
doi: 10.3390/ijerph19031480.

Effects of a 12-Week Diet versus Diet plus Aerobic and Resistance Exercise Program on Acylated and Desacylated Ghrelin, and Ghrelin O-Acyltransferase in Adolescent Girls with Obesity

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Randomized Controlled Trial

Effects of a 12-Week Diet versus Diet plus Aerobic and Resistance Exercise Program on Acylated and Desacylated Ghrelin, and Ghrelin O-Acyltransferase in Adolescent Girls with Obesity

Hyun Jun Kim et al. Int J Environ Res Public Health..

Abstract

This study investigated the effects of a 12-week diet versus diet plus aerobic and resistance exercise programme on acylated ghrelin (AG), desacylated ghrelin (DAG), and ghrelin O-acyltransferase (GOAT) concentrations in girls with obesity. We randomised 30 adolescents with obesity to a 12-week aerobic and resistance exercise group (EG) or a control group (CG). At baseline and at 4, 8, and 12 weeks, we measured their body composition, lipid profile, glucose, AG, DAG, and GOAT concentrations. In the EG, the body fat percentage decreased by 2.37% and was significantly lower than that in the CG. The DAG concentrations significantly increased by 48.3% and 27.4% in the EG and CG, respectively. At 4, 8, and 12 weeks, DAG concentrations were significantly higher in the EG than in the CG. AG concentrations were higher at week 12 than at baseline in both groups. In both groups, the GOAT concentrations increased at weeks 8 and 12; however, no between-group differences were observed in the changes in GOAT concentrations. This study showed increased DAG concentrations and non-significant changes in AG and GOAT concentrations after a 12-week aerobic and resistance exercise programme in girls with obesity. These findings suggest that an aerobic and resistance exercise programme influences appetite-regulating hormones, mainly through changes in DAG concentrations.

Keywords: acylated ghrelin; adolescent; deacylated ghrelin; exercise; ghrelin O-acyltransferase; obesity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study selection process. Of the 44 enrolled candidates, 30 participants were randomised in a 1:1 ratio to either the exercise group or control group.
Figure 2
Figure 2
Changes in the percentage body fat and metabolic hormone concentrations from baseline in girls with obesity. (a) Body fat (%), (b) aclylated ghrelin, (c) des-acylated ghrelin, (d) GOAT, (e) AG/DAG ratio. Data are expressed as medians with interquartile ranges (I bars). Asterisks indicate significant between-group differences over time (p < 0.05).p-values were calculated by repeated measures ANOVA. AG, acylated ghrelin; DAG, desacylated ghrelin; GOAT, ghrelin O-acyltransferase.
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