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Review
.2022 Jan 13;11(1):153.
doi: 10.3390/antiox11010153.

Chemical Stability of Ascorbic Acid Integrated into Commercial Products: A Review on Bioactivity and Delivery Technology

Affiliations
Review

Chemical Stability of Ascorbic Acid Integrated into Commercial Products: A Review on Bioactivity and Delivery Technology

Xin Yin et al. Antioxidants (Basel)..

Abstract

The L-enantiomer of ascorbic acid is commonly known as vitamin C. It is an indispensable nutrient and plays a key role in retaining the physiological process of humans and animals. L-gulonolactone oxidase, the key enzyme for the de novo synthesis of ascorbic acid, is lacking in some mammals including humans. The functionality of ascorbic acid has prompted the development of foods fortified with this vitamin. As a natural antioxidant, it is expected to protect the sensory and nutritional characteristics of the food. It is thus important to know the degradation of ascorbic acid in the food matrix and its interaction with coexisting components. The biggest challenge in the utilization of ascorbic acid is maintaining its stability and improving its delivery to the active site. The review also includes the current strategies for stabilizing ascorbic acid and the commercial applications of ascorbic acid.

Keywords: application; ascorbic acid; bioactivity; delivery; stability.

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Conflict of interest statement

The authors declare that Luwei Pharmaceutical Group Co. had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results and there is no conflict of interest.

Figures

Figure 1
Figure 1
Structures of L-ascorbic acid and its stereoisomer.
Figure 2
Figure 2
Degradation of L-ascorbic acid to dehydroascorbic acid and 2,3-diketogulonic acid (A) and pro-oxidant effects of ascorbic acid (B).
Figure 3
Figure 3
The proportion of patents related to ascorbic acid search terms before 2021 (a) and the number of ascorbic acid patents in each of the past 30 years (b).
See this image and copyright information in PMC

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