Review

.2022 Mar;65(3):466-499.

doi: 10.1007/s11427-021-2043-2. Epub 2021 Dec 30.

Neural circuit control of innate behaviors

Wei Xiao^#¹, Zhuo-Lei Jiao^#², Esra Senol^#³, Jiwei Yao^#⁴, Miao Zhao^#⁵, Zheng-Dong Zhao^#⁶, Xiaowei Chen^{7 8}, Peng Cao⁹, Yu Fu¹⁰, Zhihua Gao¹¹, Wei L Shen¹², Xiao-Hong Xu¹³

Affiliations

¹ Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, 310058, China.
² Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
³ Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138667, Singapore.
⁴ Center for Neurointelligence, School of Medicine, Chongqing University, Chongqing, 400030, China.
⁵ National Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100084, China.
⁶ Boston Children's Hospital, Harvard Medical School, Boston, 02115, USA.
⁷ Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing, 400038, China. xiaowei_chen@tmmu.edu.cn.
⁸ CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. xiaowei_chen@tmmu.edu.cn.
⁹ National Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100084, China. caopeng@nibs.ac.cn.
¹⁰ Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138667, Singapore. fu_yu@sbic.a-star.edu.sg.
¹¹ Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, 310058, China. zhihuagao@zju.edu.cn.
¹² School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. shenwei@shanghaitech.edu.cn.
¹³ Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. xiaohong.xu@ion.ac.cn.

^# Contributed equally.

PMID:34985643
DOI: 10.1007/s11427-021-2043-2

Review

Neural circuit control of innate behaviors

Wei Xiao et al. Sci China Life Sci.2022 Mar.

.2022 Mar;65(3):466-499.

doi: 10.1007/s11427-021-2043-2. Epub 2021 Dec 30.

Authors

Wei Xiao^#¹, Zhuo-Lei Jiao^#², Esra Senol^#³, Jiwei Yao^#⁴, Miao Zhao^#⁵, Zheng-Dong Zhao^#⁶, Xiaowei Chen^{7 8}, Peng Cao⁹, Yu Fu¹⁰, Zhihua Gao¹¹, Wei L Shen¹², Xiao-Hong Xu¹³

Affiliations

¹ Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, 310058, China.
² Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
³ Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138667, Singapore.
⁴ Center for Neurointelligence, School of Medicine, Chongqing University, Chongqing, 400030, China.
⁵ National Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100084, China.
⁶ Boston Children's Hospital, Harvard Medical School, Boston, 02115, USA.
⁷ Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing, 400038, China. xiaowei_chen@tmmu.edu.cn.
⁸ CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. xiaowei_chen@tmmu.edu.cn.
⁹ National Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100084, China. caopeng@nibs.ac.cn.
¹⁰ Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138667, Singapore. fu_yu@sbic.a-star.edu.sg.
¹¹ Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, 310058, China. zhihuagao@zju.edu.cn.
¹² School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. shenwei@shanghaitech.edu.cn.
¹³ Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. xiaohong.xu@ion.ac.cn.

^# Contributed equally.

PMID:34985643
DOI: 10.1007/s11427-021-2043-2

Abstract

All animals possess a plethora of innate behaviors that do not require extensive learning and are fundamental for their survival and propagation. With the advent of newly-developed techniques such as viral tracing and optogenetic and chemogenetic tools, recent studies are gradually unraveling neural circuits underlying different innate behaviors. Here, we summarize current development in our understanding of the neural circuits controlling predation, feeding, male-typical mating, and urination, highlighting the role of genetically defined neurons and their connections in sensory triggering, sensory to motor/motivation transformation, motor/motivation encoding during these different behaviors. Along the way, we discuss possible mechanisms underlying binge-eating disorder and the pro-social effects of the neuropeptide oxytocin, elucidating the clinical relevance of studying neural circuits underlying essential innate functions. Finally, we discuss some exciting brain structures recurrently appearing in the regulation of different behaviors, which suggests both divergence and convergence in the neural encoding of specific innate behaviors. Going forward, we emphasize the importance of multi-angle and cross-species dissections in delineating neural circuits that control innate behaviors.

Keywords: feeding; innate behavior; neural circuit; social behavior; urination.

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Neural circuit control of innate behaviors

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