Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Hindawi Limited full text link Hindawi Limited Free PMC article
Full text links

Actions

Share

.2021 Nov 11:2021:1049307.
doi: 10.1155/2021/1049307. eCollection 2021.

Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects' Periodontal, Glycemic, and Lipid Profiles

Affiliations

Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects' Periodontal, Glycemic, and Lipid Profiles

Ingra G Nicchio et al. J Diabetes Res..

Abstract

Background: Type 2 diabetes mellitus (T2DM) and periodontitis (P) commonly occur as comorbidities, but the commonalities in the genetic makeup of affected individuals is largely unknown. Since dyslipidemia is a frequent condition in these individuals, we investigate the association of genomic variations in genes involved in lipid metabolism with periodontal, glycemic, lipid profiles, and the association with periodontitis and T2DM (as comorbidities).

Methods: Based on clinical periodontal examination and biochemical evaluation, 893 subjects were divided into T2DM+P (T2DM subjects also affected by periodontitis,n = 205), periodontitis (n = 345), and healthy (n = 343). Fourteen single-nucleotide polymorphisms (SNPs) were investigated:LDLR gene (rs5925 and rs688),APOB (rs676210, rs1042031, and rs693),ABCC8 (rs6544718 and 6544713),LPL (rs28524, rs3735964, and rs1370225),HNF1A (rs2650000),APOE (rs429358 and rs7412), andHNF4A (rs1800961). Multiple linear and logistic regressions (adjusted for covariates) were made for all populations and stratified by sex and smoking habits.

Results: Individuals carryingAPOB-rs1042031-CT (mainly women and never smokers) had a lower risk of developing periodontitis and T2DM (T2DM+P); altogether, this genotype was related with healthier glycemic, lipid, and periodontal parameters. Significant disease-phenotype associations with gene-sex interaction were also found for carriers ofAPOB-rs1676210-AG,HNF4A-rs1800961-CT,ABCC8-rs6544718-CT,LPL-rs13702-CC, andLPL-rs285-CT.

Conclusions: Polymorphisms in lipid metabolism genes are associated with susceptibility to T2DM-periodontitis comorbidities, demonstrating gene-sex interaction. TheAPOB-rs1042031 was the most relevant gene marker related to glucose and lipid metabolism profiles, as well as with obesity and periodontitis.

Copyright © 2021 Ingra G. Nicchio et al.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Similar articles

See all similar articles

Cited by

References

    1. Tonetti M. S., Greenwell H., Kornman K. S. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. Journal of Periodontology . 2018;89(Supplement 1):S159–S172. doi: 10.1002/JPER.18-0006. - DOI - PubMed
    1. Tonetti M. S., Greenwell H., Kornman K. S. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. Journal of Clinical Periodontology . 2018;45(Supplement 20):S149–S161. doi: 10.1111/jcpe.12945. - DOI - PubMed
    1. Baelum V., Lopez R. Periodontal epidemiology: towards social science or molecular biology? Community Dentistry and Oral Epidemiology . 2004;32(4):239–249. doi: 10.1111/j.1600-0528.2004.00159.x. - DOI - PubMed
    1. Page R. C., Eke P. I. Case definitions for use in population-based surveillance of periodontitis. Journal of Periodontology . 2007;78(7s):1387–1399. doi: 10.1902/jop.2007.060264. - DOI - PubMed
    1. American Diabetes, A. Diagnosis and classification of diabetes mellitus. Diabetes Care . 2014;37(Supplement 1):S81–S90. doi: 10.2337/dc14-S081. - DOI - PubMed

MeSH terms

Substances

Related information

LinkOut - more resources

Full text links
Hindawi Limited full text link Hindawi Limited Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp