Comment
doi: 10.1126/science.abi9881. Epub 2021 Oct 14.Response to Comment on "Reintroduction of the archaic variant ofNOVA1 in cortical organoids alters neurodevelopment"
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- PMID:34648331
- DOI: 10.1126/science.abi9881
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Comment
Response to Comment on "Reintroduction of the archaic variant ofNOVA1 in cortical organoids alters neurodevelopment"
Roberto H Herai et al. Science..
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Abstract
Maricicet al. performed an undisclosed in silico–only whole-exome sequencing analysis of our data and found genomic alterations previously undetected in some clones. Some of the predicted alterations, if true, could change the original genotype of the clones. We failed to experimentally validate all but one of these genomic alterations, which did not affect our previous results or data interpretation.
Comment on
- Comment on "Reintroduction of the archaic variant ofNOVA1 in cortical organoids alters neurodevelopment".Maricic T, Helmbrecht N, Riesenberg S, Macak D, Kanis P, Lackner M, Pugach-Matveeva AD, Pääbo S.Maricic T, et al.Science. 2021 Oct 15;374(6565):eabi6060. doi: 10.1126/science.abi6060. Epub 2021 Oct 14.Science. 2021.PMID:34648345
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