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doi: 10.1038/s41392-021-00630-3.Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential
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- PMID:34023856
- PMCID: PMC8141052
- DOI: 10.1038/s41392-021-00630-3
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Comment
Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential
David R Sibley et al. Signal Transduct Target Ther..
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The authors declare no competing interests.
Figures
The DRD1 structures reveal orthosteric, secondary, and allosteric binding pockets. The relative locations of these pockets are indicated by colored ellipses in the central panel in which the active conformation of the DRD1 is shown in a transparent surface representation. The binding poses of selected ligands and their corresponding interacting residues (within 3.8 Å of the ligand) are shown in surrounding panels as labeled. The binding pockets are indicated by the ellipses in the same colors as the central panel. Those from Xiao, et al. are colored in cyan, those from Zhuang, et al., are colored in orange. In particular, three pairs of structures bound with dopamine, SKF83959, or LY3154207 from both groups are superimposed to demonstrate their divergences
Comment on
- Structural insights into the human D1 and D2 dopamine receptor signaling complexes.Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE.Zhuang Y, et al.Cell. 2021 Feb 18;184(4):931-942.e18. doi: 10.1016/j.cell.2021.01.027. Epub 2021 Feb 10.Cell. 2021.PMID:33571431Free PMC article.
- Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z.Xiao P, et al.Cell. 2021 Feb 18;184(4):943-956.e18. doi: 10.1016/j.cell.2021.01.028. Epub 2021 Feb 10.Cell. 2021.PMID:33571432Free PMC article.
- Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor.Zhuang Y, Krumm B, Zhang H, Zhou XE, Wang Y, Huang XP, Liu Y, Cheng X, Jiang Y, Jiang H, Zhang C, Yi W, Roth BL, Zhang Y, Xu HE.Zhuang Y, et al.Cell Res. 2021 May;31(5):593-596. doi: 10.1038/s41422-021-00482-0. Epub 2021 Mar 9.Cell Res. 2021.PMID:33750903Free PMC article.No abstract available.
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