Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

MDPI full text link MDPI Free PMC article
Full text links

Actions

Share

Review
.2021 Apr 14;9(4):830.
doi: 10.3390/microorganisms9040830.

Update on Coagulase-Negative Staphylococci-What the Clinician Should Know

Affiliations
Review

Update on Coagulase-Negative Staphylococci-What the Clinician Should Know

Ricarda Michels et al. Microorganisms..

Abstract

Coagulase-negative staphylococci (CoNS) are among the most frequently recovered bacteria in routine clinical care. Their incidence has steadily increased over the past decades in parallel to the advancement in medicine, especially in regard to the utilization of foreign body devices. Many new species have been described within the past years, while clinical information to most of those species is still sparse. In addition, interspecies differences that render some species more virulent than others have to be taken into account. The distinct populations in which CoNS infections play a prominent role are preterm neonates, patients with implanted medical devices, immunodeficient patients, and those with other relevant comorbidities. Due to the property of CoNS to colonize the human skin, contamination of blood cultures or other samples occurs frequently. Hence, the main diagnostic hurdle is to correctly identify the cases in which CoNS are causative agents rather than contaminants. However, neither phenotypic nor genetic tools have been able to provide a satisfying solution to this problem. Another dilemma of CoNS in clinical practice pertains to their extensive antimicrobial resistance profile, especially in healthcare settings. Therefore, true infections caused by CoNS most often necessitate the use of second-line antimicrobial drugs.

Keywords: coagulase-negative staphylococci; foreign body-related infections; hospital-acquired infections.

PubMed Disclaimer

Conflict of interest statement

C.P. reports receiving a research grant from MeMed Diagnostics. All other authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Overview of CoNS, according to the predominantly affected organ site or infectious syndrome, from left to right: urinary tract; cardiac valves; prosthetic joints and vascular grafts; bloodstream infections; skin and soft tissue infections; the question mark designates species of unknown clinical relevance. Most prevalent and relevant species are highlighted in blue; species are depicted in accordance with their first description, from top to bottom. Pictograms were taken with permission from Servier Medical Art [21].
Figure 2
Figure 2
Model for differentiation between contamination and infection pertaining to the finding of CoNS in a primary sterile material; BC: blood culture.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Becker K., Both A., Weißelberg S., Heilmann C., Rohde H. Emergence of coagulase-negative staphylococci. Expert. Rev. Anti. Infect. Ther. 2020;18:349–366. doi: 10.1080/14787210.2020.1730813. - DOI - PubMed
    1. Pain M., Wolden R., Jaén-Luchoro D., Salvà-Serra F., Iglesias B.P., Karlsson R., Klingenberg C., Cavanagh J.P. Staphylococcus borealis sp. nov., isolated from human skin and blood. Int. J. Syst. Evol. Microbiol. 2020;70 doi: 10.1099/ijsem.0.004499. - DOI - PubMed
    1. Becker K., Schaumburg F., Kearns A., Larsen A.R., Lindsay J.A., Skov R.L., Westh H. Implications of identifying the recently defined members of the Staphylococcus aureus complex S. argenteus and S. schweitzeri: A position paper of members of the ESCMID Study Group for Staphylococci and Staphylococcal Diseases (ESGS) Clin. Microbiol. Infect. 2019;25:1064–1070. doi: 10.1016/j.cmi.2019.02.028. - DOI - PubMed
    1. Alhussein F., Fürstenberg J., Gaupp R., Eisenbeis J., Last K., Becker S.L., Papan C. Human infections caused by Staphylococcus argenteus in Germany: Genetic characterisation and clinical implications of novel species designation. Eur. J. Clin. Microbiol. Infect. Dis. 2020;39:2461–2465. doi: 10.1007/s10096-020-03950-4. - DOI - PMC - PubMed
    1. Nurjadi D., Last K., Klein S., Boutin S., Schmack B., Mueller F., Heeg K., Ruhparwar A., Heininger A., Zanger P. Nasal colonization with Staphylococcus aureus is a risk factor for ventricular assist device infection in the first year after implantation: A prospective, single-centre, cohort study. J. Infect. 2020;80:511–518. doi: 10.1016/j.jinf.2020.02.015. - DOI - PubMed

Publication types

LinkOut - more resources

Full text links
MDPI full text link MDPI Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp