Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Frontiers Media SA full text link Frontiers Media SA Free PMC article
Full text links

Actions

Share

Review
.2021 Mar 16:12:652363.
doi: 10.3389/fendo.2021.652363. eCollection 2021.

Versatile Functions of Somatostatin and Somatostatin Receptors in the Gastrointestinal System

Affiliations
Review

Versatile Functions of Somatostatin and Somatostatin Receptors in the Gastrointestinal System

Bilal Haider Shamsi et al. Front Endocrinol (Lausanne)..

Abstract

Somatostatin (SST) and somatostatin receptors (SSTRs) play an important role in the brain and gastrointestinal (GI) system. SST is produced in various organs and cells, and the inhibitory function of somatostatin-containing cells is involved in a range of physiological functions and pathological modifications. The GI system is the largest endocrine organ for digestion and absorption, SST-endocrine cells and neurons in the GI system are a critical effecter to maintain homeostasisvia SSTRs 1-5 and co-receptors, while SST-SSTRs are involved in chemo-sensory, mucus, and hormone secretion, motility, inflammation response, itch, and painvia the autocrine, paracrine, endocrine, and exoendocrine pathways. It is also a power inhibitor for tumor cell proliferation, severe inflammation, and post-operation complications, and is a first-line anti-cancer drug in clinical practice. This mini review focuses on the current function of producing SST endocrine cells and local neurons SST-SSTRs in the GI system, discusses new development prognostic markers, phosphate-specific antibodies, and molecular imaging emerging in diagnostics and therapy, and summarizes the mechanism of the SST family in basic research and clinical practice. Understanding of endocrines and neuroendocrines in SST-SSTRs in GI will provide an insight into advanced medicine in basic and clinical research.

Keywords: enteric nervous system; gastrointestine (GI); inflammation response; somatostatin; somatostatin receptor.

Copyright © 2021 Shamsi, Chatoo, Xu, Xu and Chen.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Yavorska I, Wehr M. Somatostatin-expressing inhibitory interneurons in cortical circuits. Front Neural Circuits (2016) 10:76. 10.3389/fncir.2016.00076 - DOI - PMC - PubMed
    1. Urban-Ciecko J, Barth AL. Somatostatin-expressing neurons in cortical networks. Nat Rev Neurosci (2016) 17:401–9. 10.1038/nrn.2016.53 - DOI - PMC - PubMed
    1. Saiz-Sanchez D, Ubeda-Bañon I, Flores-Cuadrado A, Gonzalez-Rodriguez M, Villar-Conde S, Astillero-Lopez V, et al. . Somatostatin, olfaction, and neurodegeneration. Front Neurosci (2020) 14:96:96. 10.3389/fnins.2020.00096 - DOI - PMC - PubMed
    1. Kossut M, Łukomska A, Dobrzański G, Liguz-Lęcznar M. Somatostatin receptors in the brain. Postepy Biochem (2018) 64:213–21. 10.18388/pb.2018_133 - DOI - PubMed
    1. Gonkowski S, Rytel L. Somatostatin as an active substance in the mammalian enteric nervous system. Int J Mol Sci (2019) 20:4461. 10.3390/ijms20184461 - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full text links
Frontiers Media SA full text link Frontiers Media SA Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp