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Review
.2021 Feb 23;32(7):693-705.
doi: 10.1515/revneuro-2020-0106. Print 2021 Nov 25.

The glymphatic system and meningeal lymphatics of the brain: new understanding of brain clearance

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Free article
Review

The glymphatic system and meningeal lymphatics of the brain: new understanding of brain clearance

Galina Yankova et al. Rev Neurosci..
Free article

Abstract

The glymphatic system and meningeal lymphatics have recently been characterized. Glymphatic system is a glia-dependent system of perivascular channels, and it plays an important role in the removal of interstitial metabolic waste products. The meningeal lymphatics may be a key drainage route for cerebrospinal fluid into the peripheral blood, may contribute to inflammatory reaction and central nervous system (CNS) immune surveillance. Breakdowns and dysfunction of the glymphatic system and meningeal lymphatics play a crucial role in age-related brain changes, the pathogenesis of neurovascular and neurodegenerative diseases, as well as in brain injuries and tumors. This review discusses the relationship recently characterized meningeal lymphatic vessels with the glymphatic system, which provides perfusion of the CNS with cerebrospinal and interstitial fluids. The review also presents the results of human studies concerning both the presence of meningeal lymphatics and the glymphatic system. A new understanding of how aging, medications, sleep and wake cycles, genetic predisposition, and even body posture affect the brain drainage system has not only changed the idea of brain fluid circulation but has also contributed to an understanding of the pathology and mechanisms of neurodegenerative diseases.

Keywords: AQP4; amyloid; glymphatic system; immune cells; meningeal lymphatics.

© 2021 Walter de Gruyter GmbH, Berlin/Boston.

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References

    1. Abbott, N.J. (2013). Blood–brain barrier structure and function and the challenges for CNS drug delivery. J. Inherit. Metab. Dis. 36: 437–449,https://doi.org/10.1007/s10545-013-9608-0.
    1. Abbott, N.J., Pizzo, M.E., Preston, J.E., Janigro, D., and Thorne, R.G. (2018). The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’system? Acta Neuropathol. 135: 387–407,https://doi.org/10.1007/s00401-018-1812-4.
    1. Absinta, M., Ha, S.K., Nair, G., Sati, P., Luciano, N.J., Palisoc, M., Louveau, A., Zaghloul, K.A., Pittaluga, S., Kipnis, J., et al.. (2017). Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. eLife 6: e29738,https://doi.org/10.7554/elife.29738.
    1. Agrawal, S., Anderson, P., Durbeej, M., van Rooijen, N., Ivars, F., Opdenakker, G., and Sorokin, L.M. (2006). Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J. Exp. Med. 203: 1007–1019,https://doi.org/10.1084/jem.20051342.
    1. Akbar, J.J., Luetmer, P.H., Schwartz, K.M., Hunt, C.H., Diehn, F.E., and Eckel, L.J. (2012). The role of MR myelography with intrathecal gadolinium in localization of spinal CSF leaks in patients with spontaneous intracranial hypotension. Am. J. Neuroradiol. 33: 535–540,https://doi.org/10.3174/ajnr.a2815.

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