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Comment
.2021 Jan 26;118(4):e2020660118.
doi: 10.1073/pnas.2020660118.

Reply to Green and Hume: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622

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Reply to Green and Hume: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622

Fengyang Lei et al. Proc Natl Acad Sci U S A..
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Nonmicroglia peripheral immune effects after short-term CSF1R inhibition with PLX5622. Short-term exposure (7 d) to small-molecule CSF1R inhibition affects the myeloid and lymphoid compartments of the bone marrow and spleen. Flow cytometric analysis of bone marrow cells isolated from 3-mo-old CX3CR1+/EGFP mice treated with PLX5622 for 7 d shows suppression of CD11b+, CX3CR1+, CD3+, CD19+, and CD34+ bone marrow cells and CD115+, CD19+, and CD3+ splenic cells.n = 5 per group (3 mo old; mixed gender), mean ± SD, independentt test, *P < 0.05, **P < 0.01, ***P < 0.001.
Fig. 2.
Fig. 2.
Nonmicroglia peripheral immune effects after short-term CSF1R inhibition with PLX5622. Small-molecule CSF1R inhibitor, administered for 10 d, suppresses CX3CR1+ and CD115+ blood cells and reduces the number of resident and interstitial macrophages of the lung, liver, peritoneum, and retina, but not the CD45+ CD11b+ CD106+ cells of the spleen nor the F4/80lo MHCII+ CSF1R- CD11c+ peritoneal macrophages;n = 5 per group (3 mo old; mixed gender), mean ± SD, independentt test, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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References

    1. Lei F., et al. , CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages. Proc. Natl. Acad. Sci. U.S.A. 117, 23336–23338 (2020). - PMC - PubMed
    1. Paschalis E. I., et al. , Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes. Proc. Natl. Acad. Sci. U.S.A. 115, E11359–E11368 (2018). - PMC - PubMed
    1. Paschalis E. I., et al. , Microglia regulate neuroglia remodeling in various ocular and retinal injuries. J. Immunol. 202, 539–549 (2019). - PMC - PubMed
    1. Green K. N., Hume D. A., On the utility of CSF1R inhibitors. Proc. Natl. Acad. Sci. U.S.A., 10.1073/pnas.2019695118 (2021). - DOI - PMC - PubMed
    1. Badimon A., et al. , Negative feedback control of neuronal activity by microglia. Nature 586, 417–423 (2020). - PMC - PubMed

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