Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Frontiers Media SA full text link Frontiers Media SA Free PMC article
Full text links

Actions

Share

.2020 Dec 3:11:602770.
doi: 10.3389/fphar.2020.602770. eCollection 2020.

Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

Affiliations

Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

Lauri V Elsilä et al. Front Pharmacol..

Abstract

While interest in psychedelic drugs in the fields of psychiatry and neuroscience has re-emerged in recent last decades, the general understanding of the effects of these drugs remains deficient. In particular, there are gaps in knowledge on executive functions and goal-directed behaviors both in humans and in commonly used animal models. The effects of acute doses of psychedelic lysergic acid diethylamide (LSD) on reward-driven decision making were explored using the mouse version of the Iowa Gambling Task. A total of 15 mice were trained to perform in a touch-screen adaptation of the rodent version of the Iowa Gambling Task, after which single acute doses of LSD (0.025, 0.1, 0.2, 0.4 mg/kg), serotonin 2A receptor-selective agonist 25CN-NBOH (1.5 mg/kg), d-amphetamine (2.0 mg/kg), and saline were administered before the trial. 25CN-NBOH and the three lowest doses of LSD showed no statistically significant changes in option selection or in general functioning during the gambling task trials. The highest dose of LSD (0.4 mg/kg) significantly decreased premature responding and increased the omission rate, but had no effect on option selection in comparison with the saline control. Amphetamine significantly decreased the correct responses and premature responding while increasing the omission rate. In conclusion, mice can perform previously learned, reward-driven decision-making tasks while under the acute influence of LSD at a commonly used dose range.

Keywords: 25CN-NBOH; Iowa gambling task; decision-making; executive functions; hallucinogen; lysergic acid diethylamide; psychedelic.

Copyright © 2020 Elsilä, Korhonen, Hyytiä and Korpi.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Number of head twitch responses observed during the first 10 min after administration of saline, 0.1 mg/kg LSD, and 1.5 mg/kg 25CN-NBOH (repeated administration, n = 8). The data are shown as means with individual values depicted by the dots. Statistically significant differences in comparison to saline shown as **p < 0.01.
FIGURE 2
FIGURE 2
(A) The four active panels had unique reward-punishment contingencies, and the two different configurations, A and B, were used in different chambers. The panels are named after the number of sucrose rewards each of the panels gave. The first p-number indicates the probability of the reward. The punishments were given as time-out periods, the probability and the length of the time-out rising together with the reward (T.O for the time-out in seconds,p for the probability of the punishment). The R-numbers indicate the maximum number of reinforcements of each panel if it was chosen exclusively during the session(B) The development of option selection during the first 15 days of the Iowa Gambling Task phase, prior to the drug treatment sessions. Data shown as mean ± SEM.
FIGURE 3
FIGURE 3
Mean percentages of choices in each reinforcement option respectively during the different drug treatment sessions of the Iowa Gambling Task phase. None of the acute drug treatments showed statistically significant effects on the reward-driven option selection. The dots depict values of individual mice.
FIGURE 4
FIGURE 4
Mean effects of different drug treatments on performance in the Iowa Gambling Task phase. The data show the mean and the individual values of the total number of initiated trials (A), the percentage of correctly timed responses (Correct % (B)), the percentage of prematurely timed responses (Premature % (C)), and the percentage of completely omitted trials (Omission % (D)). Statistically significant differences in comparison to saline shown as ***p < 0.001 and *p < 0.05.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Adams W. K., Barkus C., Ferland J.-M. N., Sharp T., Winstanley C. A. (2017). Pharmacological evidence that 5-HT2C receptor blockade selectively improves decision making when rewards are paired with audiovisual cues in a rat gambling task. Psychopharmacology 234, 3091–3104. 10.1007/s00213-017-4696-4 - DOI - PubMed
    1. Alper K., Dong B., Shah R., Sershen H., Vinod K. Y. (2018). LSD administered as a single dose reduces alcohol consumption in C57BL/6J mice. Front. Pharmacol. 9, 994 10.3389/FPHAR.2018.00994 - DOI - PMC - PubMed
    1. Barkus C., Ferland J.-M. N., Adams W. K., Churchill G. C., Cowen P. J., Bannerman D. M., et al. (2018). The putative lithium-mimetic ebselen reduces impulsivity in rodent models. J. Psychopharmacol. 32, 1018–1026. 10.1177/0269881118784876 - DOI - PubMed
    1. Bechara A., Damasio A. R., Damasio H., Anderson S. W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50, 7–15. 10.1016/0010-0277(94)90018-3 - DOI - PubMed
    1. Bogenschutz M. P., Forcehimes A. A., Pommy J. A., Wilcox C. E., Barbosa P., Strassman R. J. (2015). Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J. Psychopharmacol. 29, 289–299. 10.1177/0269881114565144 - DOI - PubMed

Associated data

LinkOut - more resources

Full text links
Frontiers Media SA full text link Frontiers Media SA Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp