Clinical Trial
doi: 10.1002/j.1552-4604.1987.tb05600.x.Verapamil and lithium in maintenance therapy of manic patients
Affiliations
- PMID:3325531
- DOI: 10.1002/j.1552-4604.1987.tb05600.x
Item in Clipboard
Clinical Trial
Verapamil and lithium in maintenance therapy of manic patients
A J Giannini et al. J Clin Pharmacol.1987 Dec.
Display options
Format
Display options
Format
Abstract
A year-long double-blind cross-over study was used to compare the long-term therapeutic effects of lithium versus verapamil in a group of 20 manic volunteers. Subjects received each medication for six months. Before cross-over, verapamil patients showed a significant improvement after 60 days, lithium-treated patients after 180 days. After cross-over, verapamil-treated subjects showed improvement at day 240. Lithium-treated patients showed no improvement after cross-over. The data indicate that verapamil may be effective as an agent in the maintenance treatment of manic patients.
Similar articles
- Verapamil versus lithium in acute mania.Garza-Treviño ES, Overall JE, Hollister LE.Garza-Treviño ES, et al.Am J Psychiatry. 1992 Jan;149(1):121-2. doi: 10.1176/ajp.149.1.121.Am J Psychiatry. 1992.PMID:1728160Clinical Trial.
- Antimanic effects of verapamil.Giannini AJ, Houser WL Jr, Loiselle RH, Giannini MC, Price WA.Giannini AJ, et al.Am J Psychiatry. 1984 Dec;141(12):1602-3. doi: 10.1176/ajp.141.12.1602.Am J Psychiatry. 1984.PMID:6439057Clinical Trial.
- Carbamazepine versus lithium in mania: a double-blind study.Lerer B, Moore N, Meyendorff E, Cho SR, Gershon S.Lerer B, et al.J Clin Psychiatry. 1987 Mar;48(3):89-93.J Clin Psychiatry. 1987.PMID:3546274Clinical Trial.
- Lithium revisited. A re-examination of the placebo-controlled trials of lithium prophylaxis in manic-depressive disorder.Moncrieff J.Moncrieff J.Br J Psychiatry. 1995 Nov;167(5):569-73; discussion 573-4. doi: 10.1192/bjp.167.5.569.Br J Psychiatry. 1995.PMID:8564310Review.No abstract available.
- The Bech-Rafaelsen Mania Scale in clinical trials of therapies for bipolar disorder: a 20-year review of its use as an outcome measure.Bech P.Bech P.CNS Drugs. 2002;16(1):47-63. doi: 10.2165/00023210-200216010-00004.CNS Drugs. 2002.PMID:11772118Review.
Cited by
- Cluster headache: from treatment to pathophysiology.Bussone G.Bussone G.Neurol Sci. 2008 May;29 Suppl 1:S1-6. doi: 10.1007/s10072-008-0875-8.Neurol Sci. 2008.PMID:18545885Review.
- Neuropsychiatric consequences of cardiovascular medications.Huffman JC, Stern TA.Huffman JC, et al.Dialogues Clin Neurosci. 2007;9(1):29-45. doi: 10.31887/DCNS.2007.9.1/jchuffman.Dialogues Clin Neurosci. 2007.PMID:17506224Free PMC article.Review.
- Do calcium antagonists have a place in the treatment of mood disorders?Höschl C.Höschl C.Drugs. 1991 Nov;42(5):721-9. doi: 10.2165/00003495-199142050-00001.Drugs. 1991.PMID:1723370Review.No abstract available.
- Comparative study of electrocardiographic changes in patients of acute mania receiving verapamil or lithium carbonate.Singh M, Kaur S, Sehgal VK.Singh M, et al.J Clin Diagn Res. 2014 Dec;8(12):HC08-11. doi: 10.7860/JCDR/2014/9920.5268. Epub 2014 Dec 5.J Clin Diagn Res. 2014.PMID:25653966Free PMC article.
- From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms.Kabir ZD, Martínez-Rivera A, Rajadhyaksha AM.Kabir ZD, et al.Neurotherapeutics. 2017 Jul;14(3):588-613. doi: 10.1007/s13311-017-0532-0.Neurotherapeutics. 2017.PMID:28497380Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Medical