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Review
.2020 Dec;198(6):897-907.
doi: 10.1007/s00408-020-00407-5. Epub 2020 Nov 11.

Update 2020: Management of Non-Small Cell Lung Cancer

Affiliations
Review

Update 2020: Management of Non-Small Cell Lung Cancer

Mariam Alexander et al. Lung.2020 Dec.

Abstract

The past decade has seen a revolution of new advances in the management of non-small cell lung cancer (NSCLC) with remarkable progresses in screening, diagnosis, and treatment. The advances in systemic treatment have been driven primarily by the development of molecularly targeted therapeutics, immune checkpoint inhibitors, and anti-angiogenic agents, all of which have transformed this field with significantly improved patient outcomes. This review will address updates in lung cancer screening, liquid biopsy, and immunotherapy in the front-line setting. We discuss recent advances and highlight the plethora of new approvals of molecular-targeted therapy for subgroups of NSCLC patients with sensitizing EGFR, ALK, ROS1, RET, BRAF V600E, MET, and NTRK alterations.

Keywords: Immune checkpoint inhibitors; Lung cancer; Targeted therapy.

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Conflict of interest statement

Mariam Alexander and So Yeon Kim do not have any conflicts of interest to disclose. Haiying Cheng has received research funding from Genentech/Roche, Eisai, Spectrum, Regeneron, Bayer, and Vaccinex.

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References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA: Cancer J Clin. 2020;70(1):7–30. doi: 10.3322/caac.21590. - DOI - PubMed
    1. Couraud S, Zalcman G, Milleron B, Morin F, Souquet PJ. Lung cancer in never smokers–a review. Eur J Cancer. 2012;48(9):1299–1311. doi: 10.1016/j.ejca.2012.03.007. - DOI - PubMed
    1. Tang MS, Wu XR, Lee HW, Xia Y, Deng FM, Moreira AL, Chen LC, Huang WC, Lepor H. Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice. Proc Natl Acad Sci USA. 2019;116(43):21727–21731. doi: 10.1073/pnas.1911321116. - DOI - PMC - PubMed
    1. de Koning HJ, van der Aalst CM, de Jong PA, Scholten ET, Nackaerts K, Heuvelmans MA, Lammers JJ, Weenink C, Yousaf-Khan U, Horeweg N, van 'tWesteinde S, Prokop M, Mali WP, Hoesein FAAM, van Ooijen PMA, Aerts J, den Bakker MA, Thunnissen E, Verschakelen J, Vliegenthart R, Walter JE, Ten Haaf K, Groen HJM, Oudkerk M. Reduced lung-cancer mortality with volume CT screening in a randomized trial. New Engl J Med. 2020;382(6):503–513. doi: 10.1056/NEJMoa1911793. - DOI - PubMed
    1. Jemal A, Fedewa SA. Lung cancer screening with low-dose computed tomography in the United States-2010 to 2015. JAMA Oncol. 2017;3(9):1278–1281. doi: 10.1001/jamaoncol.2016.6416. - DOI - PMC - PubMed

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