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Review
.2021 Jan;17(1):7-22.
doi: 10.1038/s41582-020-00418-z. Epub 2020 Oct 26.

Applications of focused ultrasound in the brain: from thermoablation to drug delivery

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Review

Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Ying Meng et al. Nat Rev Neurol.2021 Jan.

Abstract

Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the clinic represents the culmination of decades of research. Lying at the convergence of physics, engineering, imaging, biology and neuroscience, FUS offers the ability to non-invasively and precisely intervene in key circuits that drive common and challenging brain conditions. The actions of FUS in the brain take many forms, ranging from transient blood-brain barrier opening and neuromodulation to permanent thermoablation. Over the past 5 years, we have seen a dramatic expansion of indications for and experience with FUS in humans, with a resultant exponential increase in academic and public interest in the technology. Applications now span the clinical spectrum in neurological and psychiatric diseases, with insights still emerging from preclinical models and human trials. In this Review, we provide a comprehensive overview of therapeutic ultrasound and its current and emerging indications in the brain. We examine the potential impact of FUS on the landscape of brain therapies as well as the challenges facing further advancement and broader adoption of this promising minimally invasive therapeutic alternative.

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References

    1. Aubry, J.-F. et al. The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus. J. Ther. Ultrasound 1, 13 (2013). - PubMed - PMC
    1. Tempany, C. M. C., McDannold, N. J., Hynynen, K. & Jolesz, F. A. Focused ultrasound surgery in oncology: overview and principles. Radiology 259, 39–56 (2011). - PubMed - PMC
    1. El-Hayek, Y. H. et al. Tip of the iceberg: assessing the global socioeconomic costs of Alzheimer’s disease and related dementias and strategic implications for stakeholders. J. Alzheimers Dis. 70, 323–341 (2019). - PubMed - PMC
    1. Aldape, K. et al. Challenges to curing primary brain tumours. Nat. Rev. Clin. Oncol. 16, 509–520 (2019). - PubMed - PMC
    1. Makin, S. The amyloid hypothesis on trial. Nature 559, S4–S7 (2018). - PubMed

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