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Review
.2021 Feb;41(2):727-741.
doi: 10.1007/s10792-020-01609-9. Epub 2020 Oct 11.

Clinical application of ultra-widefield fundus autofluorescence

Affiliations
Review

Clinical application of ultra-widefield fundus autofluorescence

Amin Xu et al. Int Ophthalmol.2021 Feb.

Abstract

Purpose: To review the basic principles of ultra-widefield fundus autofluorescence (UWF-FAF) and discuss its clinical application for a variety of retinal and choroidal disorders.

Methods: A systematic review of the PubMed database was performed using the search terms "ultra-widefield," "autofluorescence," "retinal disease" and "choroidal disease."

Results: UWF-FAF imaging is a recently developed noninvasive retinal imaging modality with a wide imaging range that can locate peripheral fundus lesions that traditional fundus autofluorescence cannot. Multiple commercially available ultra-widefield imaging systems, including Heidelberg Spectralis and Optomap Ultra-Widefield systems, are available to the clinician. Imaging by UWF-FAF is more comprehensive; it can reflect the content and distribution of the predominant ocular fluorophore in retinal pigment epithelial cells and evaluate the metabolic status of RPE of various retinal and choroidal disorders.

Conclusion: UWF-FAF can detect abnormalities that traditional fundus autofluorescence cannot; therefore, it can be used to better elucidate disease pathogenesis, analyze genotype-phenotype correlations, diagnose and monitor disease.

Keywords: Autofluorescence; Choroidal disease; Retinal disease; Ultra-widefield.

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