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.2021 Jan;10(1):1-3.
doi: 10.1016/j.jshs.2020.08.009. Epub 2020 Aug 28.

Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin-mediated mitophagy

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Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin-mediated mitophagy

Na Zhao et al. J Sport Health Sci.2021 Jan.

Abstract

  1. •

    Physical exercise efficiently prevents the progression of Alzheimer's disease and mitigates the risk of developing the disease.

  2. •

    Physical exercise acts against the development and progression of Alzheimer's disease via promoting mitochondrial fitness.

  3. •

    Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin–mediated mitophagy.

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Figures

Fig 1
Fig. 1
Physical exercise may exert its potential curative effects in Alzheimer's disease (AD) via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy. NAD+/NADH ↑ means that the NAD+/NADH ratio is increased; SIRT1 ↑ means that SIRT1's activity is increased; FOXO1/3–PINK1–Parkin ↑ means that FOXO1/3–PINK1–Parkin signaling pathway is up-regulated. FOXO = forkhead box O; mt. = mitochondria; NAD+ = nicotinamide adenine dinucleotide; NADH = nicotinamide adenine dinucleotide (reduced); PINK1 = phosphatase and tensin homologue (PTEN) induced putative kinase 1; SIRT1 = Sirtuin1.
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