Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Springer full text link Springer
Full text links

Actions

Share

Review
.2020 Sep;63(9):1303-1316.
doi: 10.1007/s11427-019-1687-6. Epub 2020 Jun 28.

Molecular actions of NLR immune receptors in plants and animals

Affiliations
Review

Molecular actions of NLR immune receptors in plants and animals

Jizong Wang et al. Sci China Life Sci.2020 Sep.

Abstract

NLRs constitute intracellular immune receptors in both plants and animals. Direct or indirect ligand recognition results in formation of oligomeric NLR complexes to mediate immune signaling. Over the past 20 years, rapid progress has been made in our understanding of NLR signaling. Structural and biochemical studies provide insight into molecular basis of autoinhibition, ligand recognition, and resistosome/inflammasome formation of several NLRs. In this review, we summarize these studies focusing on the structural aspect of NLRs. We also discuss the analogies and differences between plant and animal NLRs in their mechanisms of action and how the available knowledge may shed light on the signaling mechanisms of other NLRs.

Keywords: NLR immune receptor; autoihibition; molecular mechanism; pathogen perception; resistosome/inflammasome.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Adachi, H., Contreras, M.P., Harant, A., Wu, C.H., Derevnina, L., Sakai, T., Duggan, C., Moratto, E., Bozkurt, T.O., Maqbool, A., et al. (2019). An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species. eLife 8, e49956. - PubMed - PMC
    1. Ausubel, F.M. (2005). Are innate immune signaling pathways in plants and animals conserved? Nat Immunol 6, 973–979. - PubMed
    1. Axtell, M.J., and Staskawicz, B.J. (2003). Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4. Cell 112, 369–377. - PubMed
    1. Baudin, M., Hassan, J.A., Schreiber, K.J., and Lewis, J.D. (2017). Analysis of the ZAR1 immune complex reveals determinants for immunity and molecular interactions. Plant Physiol 174, 2038–2053. - PubMed - PMC
    1. Bernoux, M., Ve, T., Williams, S., Warren, C., Hatters, D., Valkov, E., Zhang, X., Ellis, J.G., Kobe, B., and Dodds, P.N. (2011). Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation. Cell Host Microbe 9, 200–211. - PubMed - PMC

Publication types

MeSH terms

Substances

LinkOut - more resources

Full text links
Springer full text link Springer
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp