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Review
.2020 Aug;20(8):453-454.
doi: 10.1038/s41577-020-0367-5.

Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children

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Review

Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children

Anne H Rowley. Nat Rev Immunol.2020 Aug.

Abstract

A new multisystem inflammatory syndrome apparently related to infection with SARS-CoV-2 has recently been reported in older children (known as MIS-C), manifested by severe abdominal pain, cardiac dysfunction and shock. Here, I discuss the similarities and differences between MIS-C and Kawasaki disease, focusing on their epidemiology, aetiology and pathophysiological mechanisms.

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Conflict of interest statement

A.H.R. is a named investigator on National Institutes of Health R21AI140029 and Provisional Patent 62/811,930 on Antibodies and Antigens of Kawasaki disease.

Figures

Fig. 1
Fig. 1. Pathogenesis of multisystem inflammatory syndrome in children: a hypothesis.
The timing of the interferon (IFN) response to SARS-CoV-2 infection can vary with viral load and genetic differences in host response. When viral load is low, IFN responses are engaged and contribute to viral clearance, resulting in mild infection. When viral load is high and/or genetic factors slow antiviral responses, virus replication can delay the IFN response and cytokine storm can result before adaptive responses clear the virus, resulting in severe disease including multisystem inflammatory syndrome in children (MIS-C). Adapted with permission from REF., Elsevier.
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References

    1. Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395:1607–1608. doi: 10.1016/S0140-6736(20)31094-1. - DOI - PMC - PubMed
    1. Verdoni L, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020;395:1771–1778. doi: 10.1016/S0140-6736(20)31103-X. - DOI - PMC - PubMed
    1. Cabrero-Hernández M, et al. Severe SARS-CoV-2 infection in children with suspected acute abdomen: a case series from a tertiary hospital in Spain. Pediatr. Infect. Dis. J. 2020 doi: 10.1097/INF.0000000000002777. - DOI - PubMed
    1. Belhadjer Z, et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. 2020 doi: 10.1161/CIRCULATIONAHA.120.048360. - DOI - PubMed
    1. Chiotos K, et al. Multisystem inflammatory syndrome in children during the COVID-19 pandemic: a case series. J. Pediatr. Infect. Dis. Soc. 2020 doi: 10.1093/jpids/piaa069. - DOI - PMC - PubMed

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