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.2020 Jul;213(1):44-44.e1.
doi: 10.5694/mja2.50657. Epub 2020 Jun 7.

Emerging viral mutants in Australia suggest RNA recombination event in the SARS-CoV-2 genome

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Emerging viral mutants in Australia suggest RNA recombination event in the SARS-CoV-2 genome

Ting-Yu Yeh et al. Med J Aust.2020 Jul.
No abstract available

Keywords: COVID-19; Epidemics; Infectious diseases; RNA virus infections; Respiratory tract infections; Virus diseases.

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Panel A: Deletions and mutations in the primary, secondary and tertiary structures of the coronavirus disease 2019 (COVID‐19) s2m RNA genetic element based on the three‐dimensional crystal structure of the SARS virus. Conventional RNA helical base pairings are indicated in italics. Sequence complements are indicated using colour‐coded brackets. The G19 mutation (arrowhead) of the Australian SARS‐CoV‐2 is shown with purple colour. Asterisks label the RNA recombination breakpoints based on analysis of 1319 Australia SARS‐CoV‐2 sequences using Recco algorithm (https://recco.bioinf.mpi-inf.mpg.de/) (P < 0.002).Panel B: Schematic representation of the s2m RNA secondary structure of the SARS virus, with tertiary structural interactions indicated as long range contacts.
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References

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