doi: 10.1016/j.jaci.2020.04.029. Epub 2020 Apr 29.
Type I IFN immunoprofiling in COVID-19 patients
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- PMID:32360285
- PMCID: PMC7189845
- DOI: 10.1016/j.jaci.2020.04.029
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Type I IFN immunoprofiling in COVID-19 patients
Sophie Trouillet-Assant et al. J Allergy Clin Immunol.2020 Jul.
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Plasma IFN-α2, IL-6, CRP, and IP-10 concentrations in COVID-19 critically ill patient cohort (n = 26).A, Plasma IFN-α concentrations (fg/mL) were determined by single-molecule array (Simoa). Fit Loess curve represents local polynomial regression performed with Loess method. CI at 95% was indicated (orange area).B-D, CRP (µg/mL), IL-6, and IP-10 (pg/mL) concentrations were measured using a multiplexed assay with the Ella platform. Normal values for healthy volunteers were indicated by grey area. Vertical bar indicates the median delay between symptom onset and intensive care unit admission.
Plasma cytokine levels and viral load in 3 SARS-COV-2–positive patients diagnosed in France.A, Plasma IFN-α concentrations (fg/mL) were determined by single-molecule array (Simoa).B-D, IL-6, CRP, and IP-10 concentrations were measured using a multiplexed assay with the Ella platform.E, Viral load is represented as cycle threshold of IP2 RT-quantitative PCR using assay designed by Pasteur Institut in Paris.
IFN score and plasma IFN-β, IFN-λ, and IFN-γ concentrations in COVID-19 critically ill patient cohort (n = 26).A, IFN score is a transcriptional signature defined by 6 IFN-stimulated genes quantified using nanostring technology and obtained from Paxgene tubes in 4 patients with COVID-19.B-D, Normal values for healthy volunteers were indicated by gray area. Vertical bar indicates median delay between symptom onset and intensive care unit admission. Concentrations of IFN-γ were quantified in only 16 of 26 patients because of lack of material.
References
- Theofilopoulos A.N., Baccala R., Beutler B., Kono D.H. Type I interferons (α/β) in immunity and autoimmunity. Annu Rev Immunol. 2005;23:307–335. - PubMed
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