Selective Serotonin Reuptake Inhibitors
- PMID:32119293
- Bookshelf ID: NBK554406
Selective Serotonin Reuptake Inhibitors
Excerpt
Selective serotonin reuptake inhibitors (SSRIs) are a class of medications most commonly prescribed to treat depression. They are often used as first-line pharmacotherapy for depression and numerous other psychiatric disorders due to their safety, efficacy, and tolerability. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the interprofessional team in the care of patients with depression and other psychiatric disorders for which SSRIs are indicated.
Copyright © 2025, StatPearls Publishing LLC.
Conflict of interest statement
Sections
References
- DeLucia V, Kelsberg G, Safranek S. Which SSRIs most effectively treat depression in adolescents? J Fam Pract. 2016 Sep;65(9):632-4. - PubMed
- Antosik-Wójcińska AZ, Stefanowski B, Święcicki Ł. Efficacy and safety of antidepressant's use in the treatment of depressive episodes in bipolar disorder - review of research. Psychiatr Pol. 2015;49(6):1223-39. - PubMed
- Coleiro B, Marshall SE, Denton CP, Howell K, Blann A, Welsh KI, Black CM. Treatment of Raynaud's phenomenon with the selective serotonin reuptake inhibitor fluoxetine. Rheumatology (Oxford) 2001 Sep;40(9):1038-43. - PubMed
- Feighner JP. Mechanism of action of antidepressant medications. J Clin Psychiatry. 1999;60 Suppl 4:4-11; discussion 12-3. - PubMed
- Xue W, Wang P, Li B, Li Y, Xu X, Yang F, Yao X, Chen YZ, Xu F, Zhu F. Identification of the inhibitory mechanism of FDA approved selective serotonin reuptake inhibitors: an insight from molecular dynamics simulation study. Phys Chem Chem Phys. 2016 Jan 28;18(4):3260-71. - PubMed
Publication types
LinkOut - more resources
Full Text Sources