.2022 Mar-Apr;28(2):83-89.

doi: 10.1016/j.pulmoe.2020.01.001. Epub 2020 Jan 31.

Evaluation of pulmonary tuberculosis diagnostic tests in children and adolescents at a pediatric reference center

Andrea M O Rossoni¹, Kathryn L Lovero², Tonny T Tahan¹, Antônio R Netto³, Marssoni D Rossoni⁴, Isabela N Almeida⁵, Elisangela A S Lizzi⁶, Afranio Kritski⁷, Cristina O Rodrigues¹

Affiliations

¹ Universidade Federal do Paraná (UFPR) the Graduate Program in Child and Adolescent Health, Curitiba, PR, Brasil.
² University of California Berkeley, School of Public Health, Division of Infectious Diseases and Vaccinology and Division of Epidemiology, Berkeley, CA, United States.
³ Universidade de São Paulo (USP), Escola de Medicina de Ribeirão Preto, Departamento de Medicina Social, Ribeirão Preto, SP, Brazil.
⁴ Universidade Federal do Paraná (UFPR), Departamento de Medicina, Hospital das Clínicas, Curitiba, PR, Brasil.
⁵ Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Laboratório de Pesquisa em Micobactérias, Belo Horizonte, MG, Brazil. Electronic address: isabelanalmeida@gmail.com.
⁶ Universidade Tecnológica Federal do Paraná (UTFPR), Departamento de Matemática, Curitiba, PR, Brazil.
⁷ Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Programa Acadêmico de Tuberculose, Rio de Janeiro, RJ, Brazil.

PMID:32014421
PMCID: PMC7392787
DOI: 10.1016/j.pulmoe.2020.01.001

Evaluation of pulmonary tuberculosis diagnostic tests in children and adolescents at a pediatric reference center

Andrea M O Rossoni et al. Pulmonology.2022 Mar-Apr.

.2022 Mar-Apr;28(2):83-89.

doi: 10.1016/j.pulmoe.2020.01.001. Epub 2020 Jan 31.

Authors

Andrea M O Rossoni¹, Kathryn L Lovero², Tonny T Tahan¹, Antônio R Netto³, Marssoni D Rossoni⁴, Isabela N Almeida⁵, Elisangela A S Lizzi⁶, Afranio Kritski⁷, Cristina O Rodrigues¹

Affiliations

¹ Universidade Federal do Paraná (UFPR) the Graduate Program in Child and Adolescent Health, Curitiba, PR, Brasil.
² University of California Berkeley, School of Public Health, Division of Infectious Diseases and Vaccinology and Division of Epidemiology, Berkeley, CA, United States.
³ Universidade de São Paulo (USP), Escola de Medicina de Ribeirão Preto, Departamento de Medicina Social, Ribeirão Preto, SP, Brazil.
⁴ Universidade Federal do Paraná (UFPR), Departamento de Medicina, Hospital das Clínicas, Curitiba, PR, Brasil.
⁵ Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Laboratório de Pesquisa em Micobactérias, Belo Horizonte, MG, Brazil. Electronic address: isabelanalmeida@gmail.com.
⁶ Universidade Tecnológica Federal do Paraná (UTFPR), Departamento de Matemática, Curitiba, PR, Brazil.
⁷ Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Programa Acadêmico de Tuberculose, Rio de Janeiro, RJ, Brazil.

PMID:32014421
PMCID: PMC7392787
DOI: 10.1016/j.pulmoe.2020.01.001

Abstract

Introduction: This study evaluates the performance of individual and combinations tests used for pediatric tuberculosis diagnosis at a reference center.

Materials and methods: Diagnostic test outcomes from children with presumed pulmonary tuberculosis evaluated from January 2005 - July 2010 were compared to a standard diagnosis made by an expert panel of physicians.

Results: Presence of at least one sign/symptom, history of contact, or abnormal chest X-ray (aCXR) individually showed the highest sensitivity (85.7%). While the combination of history of contact, at least one sign/symptom, positive tuberculin skin test, and aCXR had low sensitivity of 20%, but the specificity and a positive predictive value were 100%, respectively. The combination of tests used in the International Union Against Tuberculosis and Lung Disease and the Brazilian Ministry of Health systems showed sensitivity of 28.6% and 71.4% and specificity of 95.8% and 97.0%, respectively.

Conclusions: In the absence of a gold standard, the combination of clinical history, tuberculin skin test, and aCXR, as well as the Brazilian scoring system serve as simple, low-cost approach that can be used for pediatric TB diagnosis by first-contact care providers.

Keywords: Clinical study; Diagnosis; Pediatric hospital; Tuberculosis.

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Conflict of interest statement

Conflicts of interest

The authors declare that there is no conflict of interest.

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Evaluation of pulmonary tuberculosis diagnostic tests in children and adolescents at a pediatric reference center

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Evaluation of pulmonary tuberculosis diagnostic tests in children and adolescents at a pediatric reference center

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