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.2020:2020:10.17912/micropub.biology.000207.
doi: 10.17912/micropub.biology.000207. Epub 2020 Jan 2.

Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes

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Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes

Anna L Coleman-Hulbert et al. MicroPubl Biol.2020.
No abstract available

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Conflict of interest statement

You declare the following by submitting your article to microPublication Biology: “We declare to the best of our knowledge that the experiment is reproducible; that the submission has been approved by all authors; that the submission has been approved by the laboratory’s Principal Investigator, and that the results have not been published elsewhere. The authors declare no conflict of interest.”

Figures

Figure 1: Longevity under adult β-guanidinopropionic acid exposure
Figure 1: Longevity under adult β-guanidinopropionic acid exposure
Survival curves forC. elegans strain N2,C. briggsae strain AF16, andC. tropicalis strain JU1373 exposed to β-guanidinopropionic acid at various concentrations starting on the first day of adulthood. Only the lifespan of AF16 at 300 mM (mean=26.2 days,p=0.0123) differed significantly from the control (mean=31.5 days for AF16; control means for N2=18.8 days and JU1373=25.1 days; statistical comparisons were made with a Cox proportional hazards mixed-model using the coxme v.2.2-5 package in R (Therneau 2012; Lucanicet al. 2017)).
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