doi: 10.1055/a-0869-9899. Epub 2019 Dec 17.
[Maurice Raynaud (1834-1881) and the Mystery of "Raynaud's Phanomenon"]
[Article in German]
- PMID:31847013
- DOI: 10.1055/a-0869-9899
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[Maurice Raynaud (1834-1881) and the Mystery of "Raynaud's Phanomenon"]
[Article in German]
Ulrich Koehler et al. Dtsch Med Wochenschr.2019 Dec.
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Abstract
Maurice Raynaud first described color changes and symptoms of the fingers due to cold-induced vasospasm and restricted blood flow in his medical school thesis in 1862. Raynaud's phenomenon is common and exists as an uncomplicated primary Raynaud phenomenon and a Raynaud phenomenon secondary to underlying diseases and medication. Mechanisms contributing to altered vasoconstrictor activity are endothelial and not-endothelial. Cold-induced vasospasm is probably a thermoregulatory problem and effects are mediated by sympathetic activity and selective stimulation of alpha2c-adrenoreceptors.
© Georg Thieme Verlag KG Stuttgart · New York.
Conflict of interest statement
Die Autoren geben an, dass kein Interessenkonflikt besteht.
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