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.2019 Dec 27;82(12):3450-3455.
doi: 10.1021/acs.jnatprod.9b00840. Epub 2019 Dec 13.

Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from aMycale Marine Sponge

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Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from aMycale Marine Sponge

Samuele Sala et al. J Nat Prod..

Abstract

Seven new nitrile-bearing polyacetylenes, named albanitriles A-G, were isolated from a marine sponge of theMycale genus (Order: Poecilosclerida, Family: Mycalidae) collected near Albany, Western Australia. Structural elucidation was achieved using a combination of high-resolution mass spectrometry and ultraviolet/visible, infrared, and nuclear magnetic resonance spectroscopy. The compounds were found to possess moderate activity againstGiardia duodenalis when compared to a metronidazole positive control.

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