Third-generation cephalosporins are medications used in the management and treatment of gram-negative and gram-positive organisms. They are encompassed among the beta-lactam class of drugs. This activity describes the indications, action, and contraindications for third-generation cephalosporins as a valuable agent in the management of gram-negative meningitis, Lyme disease, Pseudomonas pneumonia, gram-negative sepsis, Streptococcal endocarditis, melioidosis, penicillinase-producing Neisseria gonorrhea, chancroid, and gram-negative osteomyelitis. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the interprofessional healthcare team in the treatment of patients with gram-positive and gram-negative infections and related conditions.

Disclosure:Vijay Arumugham declares no relevant financial relationships with ineligible companies.

Disclosure:Rahul Gujarathi declares no relevant financial relationships with ineligible companies.

Disclosure:Marco Cascella declares no relevant financial relationships with ineligible companies.