The effects of a shampoo containing zinc pyrithione on the control of dandruff
- PMID:3158327
- DOI: 10.1111/j.1365-2133.1985.tb02314.x
The effects of a shampoo containing zinc pyrithione on the control of dandruff
Abstract
Thirty-two subjects who suffered from dandruff participated in a study in which one-half of the head was washed with a shampoo containing 1% zinc pyrithione (ZPT) and the other half was washed with the same shampoo without ZPT. Four groups, eight subjects per group, were shampooed one, three, six or nine times (shampoo frequency twice per week). Clinical dandruff gradings of each half of the head were made 4 days after the last shampoo in each group, when scalp biopsy samples were also taken from each half of the head. Measurements of labelling index (LI), mean epidermal thickness (MET), and assessment of the numbers of PAS- and Gram-positive micro-organisms were made on the biopsy samples. There was a progressive reduction in dandruff on the sides of the head treated with the ZPT shampoo, the differences relative to the placebo-treated areas being statistically significant after three, six and nine washes. There were no significant differences in LI between treatment groups and the MET was shown to vary according to the treatment and the number of washes. There was a significant reduction in the number of PAS-positive micro-organisms (but not Gram-positive micro-organisms) on the ZPT-treated areas.
Similar articles
- A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis.Piérard-Franchimont C, Goffin V, Decroix J, Piérard GE.Piérard-Franchimont C, et al.Skin Pharmacol Appl Skin Physiol. 2002 Nov-Dec;15(6):434-41. doi: 10.1159/000066452.Skin Pharmacol Appl Skin Physiol. 2002.PMID:12476017Clinical Trial.
- Dandruff/seborrhoeic dermatitis is characterized by an inflammatory genomic signature and possible immune dysfunction: transcriptional analysis of the condition and treatment effects of zinc pyrithione.Mills KJ, Hu P, Henry J, Tamura M, Tiesman JP, Xu J.Mills KJ, et al.Br J Dermatol. 2012 Jun;166 Suppl 2:33-40. doi: 10.1111/j.1365-2133.2012.10863.x.Br J Dermatol. 2012.PMID:22670617Clinical Trial.
- Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.Schwartz JR, Henry JP, Kerr KM, Flagler MJ, Page SH, Redman-Furey N.Schwartz JR, et al.J Cosmet Dermatol. 2018 Feb;17(1):105-111. doi: 10.1111/jocd.12355. Epub 2017 May 14.J Cosmet Dermatol. 2018.PMID:28504468Clinical Trial.
- Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics.Schwartz JR.Schwartz JR.J Drugs Dermatol. 2016 Feb;15(2):140-4.J Drugs Dermatol. 2016.PMID:26885780Review.
- An overview of experience with ketoconazole shampoo.Ive FA.Ive FA.Br J Clin Pract. 1991 Winter;45(4):279-84.Br J Clin Pract. 1991.PMID:1839767Review.
Cited by
- Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss.Rim JH, Choi JY, Jung J, Gee HY.Rim JH, et al.Int J Mol Sci. 2021 Mar 2;22(5):2510. doi: 10.3390/ijms22052510.Int J Mol Sci. 2021.PMID:33801540Free PMC article.Review.
- Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa.Warrilow AG, Price CL, Parker JE, Rolley NJ, Smyrniotis CJ, Hughes DD, Thoss V, Nes WD, Kelly DE, Holman TR, Kelly SL.Warrilow AG, et al.Sci Rep. 2016 Jun 13;6:27690. doi: 10.1038/srep27690.Sci Rep. 2016.PMID:27291783Free PMC article.
- Targeted Delivery of Zinc Pyrithione to Skin Epithelia.Mangion SE, Holmes AM, Roberts MS.Mangion SE, et al.Int J Mol Sci. 2021 Sep 8;22(18):9730. doi: 10.3390/ijms22189730.Int J Mol Sci. 2021.PMID:34575891Free PMC article.Review.
- Zinc therapy in dermatology: a review.Gupta M, Mahajan VK, Mehta KS, Chauhan PS.Gupta M, et al.Dermatol Res Pract. 2014;2014:709152. doi: 10.1155/2014/709152. Epub 2014 Jul 10.Dermatol Res Pract. 2014.PMID:25120566Free PMC article.Review.
- Dandruff: the most commercially exploited skin disease.Ranganathan S, Mukhopadhyay T.Ranganathan S, et al.Indian J Dermatol. 2010 Apr-Jun;55(2):130-4. doi: 10.4103/0019-5154.62734.Indian J Dermatol. 2010.PMID:20606879Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous