Editorial
doi: 10.1080/20013078.2019.1648167. eCollection 2019.Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature
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- PMID:31489144
- PMCID: PMC6711079
- DOI: 10.1080/20013078.2019.1648167
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Editorial
Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature
Kenneth W Witwer et al. J Extracell Vesicles..
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Keywords: MISEV; MISEV2018; Nomenclature; ectosome; exosome; extracellular vesicle; microparticle; microvesicle; outer membrane vesicle; terminology.
Figures
Usage and rate of increase of common EV terms in PubMed-indexed articles. Top left: number of published articles from 1990 to 2018 including each term as a text word (singular or plural), “Ectosome” here also encompasses terms such as microvesicle and microparticle. Searches were designed with Boolean operators in an attempt to eliminate articles unrelated to EVs, such as those including alternative definitions as alluded to in the text (e.g. the intracellular “exosome” complex, the sponge “ectosome”, synthetic microparticles, and intracellular microvesicles). Nevertheless, entries from 1990 to 2007 were curated manually to remove non-EV articles. By 2008, non-EV usages fell to<10% of the total, and manual curation was not done for subsequent years. Since some articles use more than one term, the total (“All”) may be less than the sum of the individual terms. Note that false negatives and positives from the searches are possible, so all numbers should be taken as approximate. Bottom left: year-to-year change in usage of each term, starting with 2008 and expressed as per cent change (0 = no change). Top right: number of articles with titles containing “exosome” (or “exosomal”) or “extracellular vesicle”. Bottom right: year-to-year change in article title usage.
References
- Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7(1):1535750 Available from:https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1535750 - DOI - PMC - PubMed
- Fox AS, Duggleby WF, Gelbart WM, et al. DNA-induced transformation in Drosophila: evidence for transmission without integration. Proc Natl Acad Sci U S A. 1970;67(4):1834–7. Available from:http://www.ncbi.nlm.nih.gov/pubmed/5275381 - PMC - PubMed
- Fox AS, Yoon SB.. DNA-induced transformation in Drosophila: locus-specificity and the establishment of transformed stocks. Proc Natl Acad Sci U S A. 1970;67(3):1608–1615. Available from:http://www.ncbi.nlm.nih.gov/pubmed/5274483 - PMC - PubMed
- Fox AS, Yoon SB, Gelbart WM. DNA-induced transformation in Drosophila: genetic analysis of transformed stocks. Proc Natl Acad Sci U S A. 1971;68(2):342–346. Available from:http://www.ncbi.nlm.nih.gov/pubmed/5277082 - PMC - PubMed
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