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.2018 May 9;3(5):5078-5082.
doi: 10.1021/acsomega.8b00544. eCollection 2018 May 31.

Efficient New Protocols for Converting Primary Amides into Nitriles Initiated by P(NMe2)3, PCl3, or P(OPh)3

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Efficient New Protocols for Converting Primary Amides into Nitriles Initiated by P(NMe2)3, PCl3, or P(OPh)3

Imen Talbi et al. ACS Omega..

Abstract

Three efficient and high-yielding procedures have been developed for the conversion of primary amides into nitriles, mediated by hitherto unexplored P(NMe2)3, PCl3, or P(OPh)3. The reactions were conducted under operationally simple and mild conditions and displayed broad substrate scope and good functional group tolerance.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Scheme 1
Scheme 1. Proposed Reaction Mechanism for Protocols A, B, and C
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