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.2019 Jan 1:2019:baz079.
doi: 10.1093/database/baz079.

IRAM: virus capsid database and analysis resource

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IRAM: virus capsid database and analysis resource

Iman Almansour et al. Database (Oxford)..

Abstract

IRAM is an online, open access, comprehensive database and analysis resource for virus capsids. The database includes over 200 000 hierarchically organized capsid-associated nucleotide and amino acid sequences, as well as 193 capsids structures of high resolution (1-5 Å). Each capsid's structure includes a data file for capsid domain (PDB), capsid symmetry unit (PDB) and capsid structure information (PSF); these contain capsid structural information that is necessary to run further computational studies. Physicochemical properties analysis is implemented for calculating capsid total charge at given radii and for calculating charge distributions. This resource includes BLASTn and BLASTp tools, which can be applied to compare nucleotide and amino acid sequences. The diverse functionality of IRAM is valuable to researchers because it integrates different aspects of virus capsids via a user-friendly interface. Such data are critical for studying capsid evolution and patterns of conservation. The IRAM database can also provide initial necessary information for the design of synthetic capsids for various biotechnological applications.

© The Author(s) 2019. Published by Oxford University Press.

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Figures

Figure 1
Figure 1
Snapshot of IRAM homepage.
Figure 2
Figure 2
Detailed result of capsid nucleotide and amino acid sequences of a selected virus.
Figure 3
Figure 3
Details of a selected capsids structure. Capsid files: capsid domain PDB, full capsids PDB, full capsid PSF and capsid FASTA.
Figure 4
Figure 4
Physical properties analysis. Histogram showing the charge distribution of a selected capsid PDB ID, where Rin represents inner capsid radii and Rout represents outer capsid radii.
See this image and copyright information in PMC

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References

    1. Fraenkel-Conrat H. and Williams R.C. (1955) Reconstitution of active tobacco mosaic virus from its inactive protein and nucleic acid components. Proc. Natl. Acad. Sci. USA, 41, 690–698. - PMC - PubMed
    1. Crick F.H. and Watson J.D. (1956) Structure of small viruses. Nature, 177, 473–475. - PubMed
    1. Crick F.H. and Watson J.D. (1957) Virus structure: general principles. Nat Viruses, 5, 5–18.
    1. Grimes J.M., Burroughs J.N., Gouet P. et al. (1998) The atomic structure of the bluetongue virus core. Nature, 395, 470. - PubMed
    1. Reinisch K.M., Nibert M.L. and Harrison S.C. (2000) Structure of the reovirus core at 3.6 A resolution. Nature, 404, 960. - PubMed

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