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Review
.2018 Aug;8(7):709-718.
doi: 10.21037/qims.2018.08.02.

The 8th lung cancer TNM classification and clinical staging system: review of the changes and clinical implications

Affiliations
Review

The 8th lung cancer TNM classification and clinical staging system: review of the changes and clinical implications

Wanyin Lim et al. Quant Imaging Med Surg.2018 Aug.

Abstract

Lung cancer is the leading cause of cancer death in both men and women. Clinical staging plays a crucial role in predicting survivor as well as influencing management option in lung cancer patients. Guidelines are constantly being reviewed as more data becomes available to provide the most accurate prognostic markers, hence aiding in the clinical detection and staging of lung cancer. Since its introduction in the 1970s, the TNM staging has undergone significant revisions with the latest, 8th edition, being effective internationally from 2018. This edition re-categorizes the tumour size and other non-quantitative tumour descriptors (T), and further subclassifies extra-thoracic metastases (M). The clinical nodal (N) classifier is unchanged as the earlier version correlates well with prognosis. The downstream effects on staging to accommodate for the new T and M classifications are highlighted. The survival is inversely proportional to every centimeter increase in tumour size up till 7 cm, where the same prognosis as a T4 disease is reached. Hence, some of the T-classifiers based on size of the tumour is upstaged to reflect that. Invasion of the diaphragm is considered T4 instead of T3. On the other hand, involvement of the main bronchus regardless of tumour distance to carina as well as atelectasis is down-staged from a T3 to a T2 disease. Since the 7th edition, new entities of lung tumour known as adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) have been introduced. The T-defining features are also described in this manuscript. Extrathoracic metastases that were classified as M1b in the 7th edition is further subcategorized into M1b and M1c in the 8th edition, to better define oligometastasis which has a better prognosis, and may benefit from more aggressive local therapy. This overview aims to provide radiologists with a description of the changes in the latest edition including staging of subsolid and multiple nodules, outline potential limitations of this 8th edition, as well as discussion on the implications on treatment.

Keywords: AJCC; Lung cancer; TNM 8th edition; UICC; malignancy; metastasis; neoplasm; staging.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Fused PET-CT showing complete right lung atelectasis secondary to a 5-cm obstructing tumour in the right hilum. This is a T2 tumour in the 8th edition, and would have been a T3 based on previous 7th edition.
Figure 2
Figure 2
Lobulated 5 cm lung mass in the left lingula involving the diaphragm. This is a T4 disease based on TNM 8th edition; previously a T3.
Figure 3
Figure 3
Left lower lobe apical segment pure ground glass nodule, 31 mm, T1a.
Figure 4
Figure 4
Two persistent pure ground-glass nodules measuring 6 and 9 mm, and a subsolid nodule with at least two islands of solid component, the largest solid component being 7 mm, is being followed-up in a 76-year-old smoker. If these were adenocarcinoma, the clinical T descriptor, based on IASCL recommendations, would be cT1a [3]. The ‘[3]’ indicates total number of lesions, and the T1a indicates that the most invasive of the three lesions, is less than 1cm.
Figure 5
Figure 5
Biopsy proven mucinous adenocarcinoma in a 50-year-old male, manifesting as bilateral consolidative changes with areas of cyst formation. As per the new TNM staging, given the bilateral lung involvement, this would be M1a.
Figure 6
Figure 6
Coronal-oblique post contrast brain illustrating two hyperenhancing brain parenchyma metastatic deposits in a patient with known NSCLC. There is effacement of left lateral ventricle. This is classified as an M1c in the 8th edition, whereas previously, extrathoracic metastasis, regardless of number of lesions, were classified as M1b. NSCLC, non-small cell lung cancer.
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