Neglected tropical diseases and vitamin B12: a review of the current evidence
- PMID:30165408
- PMCID: PMC6457089
- DOI: 10.1093/trstmh/try078
Neglected tropical diseases and vitamin B12: a review of the current evidence
Erratum in
- Corrigendum to: Neglected tropical diseases and vitamin B12: a review of the current evidence.Transactions of the Royal Society of Tropical Medicine and Hygiene, 2018;112(10):423–35; https://doi.org/10.1093/trstmh/try078.Transactions of the Royal Society of Tropical Medicine and Hygiene, 2018;112(10):423–35; https://doi.org/10.1093/trstmh/try078.Trans R Soc Trop Med Hyg. 2019 May 1;113(5):292. doi: 10.1093/trstmh/trz013.Trans R Soc Trop Med Hyg. 2019.PMID:30927006Free PMC article.No abstract available.
Abstract
Vitamin B12 deficiency is an urgent public health problem that disproportionately affects individuals in low- and middle-income settings, where the burden of neglected tropical diseases (NTDs) is also unacceptably high. Emerging evidence supports a potential role of micronutrients in modulating the risk and severity of NTDs. However, the role of vitamin B12 in NTD pathogenesis is unknown. This systematic review was conducted to evaluate the evidence on the role of vitamin B12 in the etiology of NTDs. Ten studies were included in this review: one study using an in vitro/animal model, eight observational human studies and one ancillary analysis conducted within an intervention trial. Most research to date has focused on vitamin B12 status and helminthic infections. One study examined the effects of vitamin B12 interventions in NTDs in animal and in vitro models. Few prospective studies have been conducted to date to examine the role of vitamin B12 in NTDs. The limited literature in this area constrains our ability to make specific recommendations. Larger prospective human studies are needed to elucidate the role of vitamin B12 in NTD risk and severity in order to inform interventions in at-risk populations.
Figures
Similar articles
- The burden of neglected tropical diseases in Ethiopia, and opportunities for integrated control and elimination.Deribe K, Meribo K, Gebre T, Hailu A, Ali A, Aseffa A, Davey G.Deribe K, et al.Parasit Vectors. 2012 Oct 24;5:240. doi: 10.1186/1756-3305-5-240.Parasit Vectors. 2012.PMID:23095679Free PMC article.Review.
- Tailoring mass drug administration to context: implementation research is critical in achieving equitable progress in the control and elimination of helminth neglected tropical diseases in sub-Saharan Africa.Dean L, Page S, Hawkins K, Stothard R, Thomson R, Wanji S, Gyapong M, Anagbogu I, Molyneux D, Theobald S.Dean L, et al.Int Health. 2016 Jul;8(4):233-4. doi: 10.1093/inthealth/ihw031.Int Health. 2016.PMID:27481833
- RRR for NNN-a rapid research response for the Neglected Tropical Disease NGDO Network: a novel framework to challenges faced by the global programs targeting neglected tropical diseases.Toledo CE, Jacobson J, Wainwright EC, Ottesen EA, Lammie PJ.Toledo CE, et al.Int Health. 2016 Mar;8 Suppl 1(Suppl 1):i12-4. doi: 10.1093/inthealth/ihv072.Int Health. 2016.PMID:26940303Free PMC article.
- Neglected Tropical Diseases in Italy: introducing IN-NTD, the Italian network for NTDs.Casulli A, Antinori S, Bartoloni A, D'Amelio S, Gabrielli AF, Gazzoli G, Rinaldi L, Bruschi F; IN-NTD network.Casulli A, et al.Parasitology. 2023 Oct;150(12):1082-1088. doi: 10.1017/S0031182023000422. Epub 2023 May 9.Parasitology. 2023.PMID:37264942Free PMC article.Review.
- Neglected tropical diseases in Republic of Guinea: disease endemicity, case burden and the road towards the 2030 target.Cherif MS, Keita M, Dahal P, Guilavogui T, Beavogui AH, Diassy L, Conde M, Touré A, Delamou A.Cherif MS, et al.Int Health. 2023 Sep 1;15(5):490-504. doi: 10.1093/inthealth/ihad036.Int Health. 2023.PMID:37232124Free PMC article.Review.
Cited by
- Genomics and Bioinformatics in One Health: Transdisciplinary Approaches for Health Promotion and Disease Prevention.Scarpa F, Casu M.Scarpa F, et al.Int J Environ Res Public Health. 2024 Oct 9;21(10):1337. doi: 10.3390/ijerph21101337.Int J Environ Res Public Health. 2024.PMID:39457310Free PMC article.
- Public Health Aspects in the Prevention and Control of Vitamin Deficiencies.Darnton-Hill I.Darnton-Hill I.Curr Dev Nutr. 2019 Jun 21;3(9):nzz075. doi: 10.1093/cdn/nzz075. eCollection 2019 Sep.Curr Dev Nutr. 2019.PMID:31598578Free PMC article.Review.
- Anemia in a young Guinean male.Wilcox NS, Tapé C, Cordisco AJ, Than MT, Zuroff L, Dobkin J, Massa RC, Lytle AG, Bagg A, Min H, Glaser LJ, Kosseim LM.Wilcox NS, et al.Clin Case Rep. 2021 Aug 6;9(8):e04593. doi: 10.1002/ccr3.4593. eCollection 2021 Aug.Clin Case Rep. 2021.PMID:34401166Free PMC article.
- Vitamin B12 deficiency presenting with a pancytopenia in pregnancy.Dunphy L, Tang AW.Dunphy L, et al.BMJ Case Rep. 2023 Jan 12;16(1):e249955. doi: 10.1136/bcr-2022-249955.BMJ Case Rep. 2023.PMID:36634987Free PMC article.
- Diagnostic reliability of serum active B12 (holo-transcobalamin) in true evaluation of vitamin B12 deficiency: Relevance in current perspective.Dastidar R, Sikder K.Dastidar R, et al.BMC Res Notes. 2022 Oct 22;15(1):329. doi: 10.1186/s13104-022-06224-8.BMC Res Notes. 2022.PMID:36273211Free PMC article.
References
- Hotez PJ, Molyneux DH, Fenwick A et al. . Control of neglected tropical diseases. N Engl J Med 2007;357(10):1018–27. - PubMed
- Feasey N, Wansbrough-Jones M, Mabey DCW, Solomon AW. Neglected tropical diseases. Br Med Bull 2010;93(1):179–200. - PubMed
- Fenwick A. The global burden of neglected tropical diseases. Public Health 2012;126(3):233–6. - PubMed
Publication types
MeSH terms
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources