Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Elsevier Science full text link Elsevier Science Free PMC article
Full text links

Actions

Share

.2018 Sep 1:128:167-179.
doi: 10.1016/j.appet.2018.06.014. Epub 2018 Jun 8.

Is brain response to food rewards related to overeating? A test of the reward surfeit model of overeating in children

Affiliations

Is brain response to food rewards related to overeating? A test of the reward surfeit model of overeating in children

Shana Adise et al. Appetite..

Abstract

The reward surfeit model of overeating suggests that heightened brain response to rewards contributes to overeating and subsequent weight gain. However, previous studies have not tested whether brain response to reward is associated with food intake, particularly during childhood, a period of dynamic development in reward and inhibitory control neurocircuitry. We conducted functional magnetic resonance imaging (fMRI) with 7-11-year-old children (n = 59; healthy weight, n = 31; overweight, n = 28; 54% female) while they played a modified card-guessing paradigm to examine blood-oxygen-level-dependent (BOLD) response to anticipating and winning rewards (food, money, neutral). Food intake was assessed at three separate meals that measured different facets of eating behavior: 1) typical consumption (baseline), 2) overindulgence (palatable buffet), and 3) eating in the absence of hunger (EAH). A priori regions of interest included regions implicated in both reward processing and inhibitory control. Multiple stepwise regressions were conducted to examine the relationship between intake and BOLD response to rewards. Corrected results showed that a greater BOLD response in the medial prefrontal cortex for anticipating food compared to money positively correlated with how much children ate at the baseline and palatable buffet meals. BOLD response in the dorsolateral prefrontal cortex for winning food compared to money was positively correlated with intake at the palatable buffet meal and EAH. All aforementioned relationships were independent of child weight status. Findings support the reward surfeit model by showing that increased brain response to food compared to money rewards positively correlates with laboratory measures of food intake in children.

Trial registration: ClinicalTrials.govNCT02855398.

Keywords: Childhood obesity; Eating behavior; Inhibitory control; Reward processing; fMRI.

Copyright © 2018. Published by Elsevier Ltd.

PubMed Disclaimer

Conflict of interest statement

No authors report any conflicts of interest.

Figures

Figure 1
Figure 1
An overview of study enrollment.
Figure 2
Figure 2
Localization of (A) medial prefrontal cortex (mPFC)(x = 0,y = 52,z = 20). (B) Partialcorrelations between intake (kcal) at the baseline meal and BOLD response in themPFC BOLD for anticipating food vs. money (β = 0.32,p = 0.009). (C)Localization of the left orbitofrontal cortex (x =−24,y = 32,z =−14). (D) Partial correlations betweenintake (kcal) at the baseline meal and BOLD response in the left orbitofrontalcortex (OFC) for anticipating food vs. money (β = 0.32,p = 0.008). Partial correlations are adjusted forBMI z-score.
Figure 3
Figure 3
Localization of the (A) right dorsolateralprefrontal cortex (dlPFC) (R1x = 44,y = 38,z = 42; R2x = 36,y = 38,z = −30). (B)Partial correlations between intake (kcal) during EAH and BOLD response in theright (R1) dlPFC for food vs. money (β = 0.42,p = 0.002). (C)Partial correlations between intake (kcal) during EAH and BOLD response in theright (R2) dlPFC for winning food vs. money (β = 0.38,p = 0.009). Partial correlations are adjusted forBMIz-score.
Figure 4
Figure 4
Localization of the (A) medial prefrontal cortex(mPFC) (x = 0,y = 52,z = 20). (B) Partialcorrelations between intake (in kcals) at the palatable buffet meal and BOLDresponse in the mPFC for anticipating food vs. money (β = 0.29,p = 0.02). (C)Localization of the left amygdala (x = −22,y = −4,z =−18). (D) Partial correlations betweenintake (in kcals) at the palatable buffet meal and BOLD response in the leftamygdala for winning food vs. money (β = 0.36,p = 0.004). (E)Localization of the right dorsolateral prefrontal cortex (dlPFC) (R1x = 44,y = 38,z = 42). (F) Partialcorrelations between intake (in kcals) at the palatable buffet meal and BOLDresponse in the R1 dlPFC for winning food vs. money (β = 0.39p = 0.001). Partial correlations adjusted for BMIz-score.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Adise S, Geier CF, Roberts NR, White CN, Keller KL. Food or money? Children’s brains respond differently to rewards regardless of weight status. Pediatric Obesity. 2018 Under Review. - PubMed
    1. Babbs RK, Sun X, Felsted J, Chouinard-Decorte F, Veldhuizen MG, Small DM. Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity. Physiology & Behavior. 2013;121:103–111. doi: 10.1016/j.physbeh.2013.03.025. - DOI - PMC - PubMed
    1. Balodis IM, Kober H, Worhunsky PD, White MA, Stevens MC, Pearlson GD, Potenza MN. Monetary reward processing in obese individuals with and without binge eating disorder. Biological Psychiatry. 2013;73(9):877–886. doi: 10.1016/j.biopsych.2013.01.014. - DOI - PMC - PubMed
    1. Batterink L, Yokum S, Stice E. Body mass correlates inversely with inhibitory control in response to food among adolescent girls: An fMRI study. NeuroImage. 2010;52(4):1696–1703. doi: 10.1016/j.neuroimage.2010.05.059. - DOI - PMC - PubMed
    1. Berkman E, Falk EB. Beyond Brain Mapping: Using Neural Measures to Predict Real-World Outcomes. Current Directions in Psychological Science. 2013;22(1):45–50. doi: 10.1177/0963721412469394.Beyond. - DOI - PMC - PubMed

Publication types

MeSH terms

Associated data

Related information

Grants and funding

LinkOut - more resources

Full text links
Elsevier Science full text link Elsevier Science Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp