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doi: 10.1073/pnas.1803645115. Epub 2018 Mar 28.BDNF signaling: Harnessing stress to battle mood disorder
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- PMID:29592951
- PMCID: PMC5899500
- DOI: 10.1073/pnas.1803645115
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Comment
BDNF signaling: Harnessing stress to battle mood disorder
Pawel Licznerski et al. Proc Natl Acad Sci U S A..
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The authors declare no conflict of interest.
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BDNF binding to TrkB receptor activates signaling cascades responsible for neuronal survival and synaptic plasticity. ProBDNF binds p75NTR and triggers long-term depression and apoptosis. Upon stress, including high-frequency synaptic stimulation, Bcl-2 is recruited to mitochondria to decrease the production of reactive oxygen species (ROS) and enhance effective ATP production; this supports relevant gene transcription and protein translation. Mild acute stress or high frequency synaptic activity recruit and may require BDNF signaling during learning and memory formation and for antidepressant coping strategies.
Comment on
- Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus.Marshall J, Zhou XZ, Chen G, Yang SQ, Li Y, Wang Y, Zhang ZQ, Jiang Q, Birnbaumer L, Cao C.Marshall J, et al.Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3549-E3558. doi: 10.1073/pnas.1722493115. Epub 2018 Mar 5.Proc Natl Acad Sci U S A. 2018.PMID:29507199Free PMC article.
References
- Otte C, et al. Major depressive disorder. Nat Rev Dis Primers. 2016;2:16065. - PubMed
- Kristensen P, Weisæth L, Heir T. Bereavement and mental health after sudden and violent losses: A review. Psychiatry. 2012;75:76–97. - PubMed
- Vicario-Abejón C, Owens D, McKay R, Segal M. Role of neurotrophins in central synapse formation and stabilization. Nat Rev Neurosci. 2002;3:965–974. - PubMed
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