Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi
- PMID:29432791
- DOI: 10.1016/j.dci.2018.02.008
Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi
Abstract
Teleost fish are unique in having type I and type II interferons (IFNs) only, and the type I IFNs are classified into Group one and Group two based on the presence of two or four cysteines respectively, and are further classified into seven subgroups. In the present study, three distinct type I IFNs, IFNc, IFNd and IFNh, have been identified in the genome sequences of a perciform fish, the mandarin fish Siniperca chuatsi. These IFNs are induced following the stimulation of Polyinosinic polycytidylic acid (poly(I:C)) and Resiquimod (R848) either in vivo or in vitro. But, the infectious spleen and kidney necrosis virus (ISKNV) infection caused a delayed response of IFNs, which may be resulted from the viral inhibition of type I IFN production and related signalling. The three receptor subunits, cytokine receptor family B 1 (CRFB1), CRFB2 and CRFB5 are also expressed in a similar manner as observed for the IFNs, and IFNc, IFNd and IFNh use preferentially the receptor complex, CRFB2 and CRFB5, CRFB1 and CRFB5, CRFB1 and CRFB5 respectively for their effective signalling in the induction of IFN-stimulated genes (ISGs). Moreover, the IFNs are able to induce their own expression, and also the IRF3 and IRF7 expression, leading to the amplification of IFN cascade. It is further revealed that these three IFNs are transcribed differently by IRF7 and IRF3. The composition, function, signalling and transcription of type I IFNs have been investigated in detail in a teleost fish.
Keywords: CRFB; Cytokine receptor family B; IRF3; IRF7; STAT1; STAT2; Teleost fish; Type I IFN.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Similar articles
- Composition and transcription of all interferon regulatory factors (IRFs), IRF1‒11 in a perciform fish, the mandarin fish, Siniperca chuatsi.Laghari ZA, Li L, Chen SN, Huo HJ, Huang B, Zhou Y, Nie P.Laghari ZA, et al.Dev Comp Immunol. 2018 Apr;81:127-140. doi: 10.1016/j.dci.2017.11.015. Epub 2017 Nov 26.Dev Comp Immunol. 2018.PMID:29180032
- Identification and characterization of tilapia CRFB1, CRFB2 and CRFB5 reveals preferential receptor usage of three IFN subtypes in perciform fishes.Gan Z, Cheng J, Chen S, Hou J, Li N, Xia H, Xia L, Lu Y, Nie P.Gan Z, et al.Fish Shellfish Immunol. 2020 Dec;107(Pt A):194-201. doi: 10.1016/j.fsi.2020.10.002. Epub 2020 Oct 1.Fish Shellfish Immunol. 2020.PMID:33011433
- The discovery and comparative expression analysis of three distinct type I interferons in the perciform fish, meagre (Argyrosomus regius).Milne DJ, Campoverde C, Andree KB, Chen X, Zou J, Secombes CJ.Milne DJ, et al.Dev Comp Immunol. 2018 Jul;84:123-132. doi: 10.1016/j.dci.2018.02.001. Epub 2018 Feb 7.Dev Comp Immunol. 2018.PMID:29425805
- Myxovirus resistance (Mx) gene and its differential expression regulated by three type I and two type II IFNs in mandarin fish, Siniperca chuatsi.Li L, Chen SN, Laghari ZA, Huo HJ, Hou J, Huang L, Li N, Nie P.Li L, et al.Dev Comp Immunol. 2020 Apr;105:103604. doi: 10.1016/j.dci.2019.103604. Epub 2019 Dec 30.Dev Comp Immunol. 2020.PMID:31899304Review.
- The antiviral innate immune response in fish: evolution and conservation of the IFN system.Langevin C, Aleksejeva E, Passoni G, Palha N, Levraud JP, Boudinot P.Langevin C, et al.J Mol Biol. 2013 Dec 13;425(24):4904-20. doi: 10.1016/j.jmb.2013.09.033. Epub 2013 Sep 27.J Mol Biol. 2013.PMID:24075867Review.
Cited by
- Structural and Functional Analyses of Type I IFNa Shed Light Into Its Interaction With Multiple Receptors in Fish.Wang Z, Xu J, Feng J, Wu K, Chen K, Jia Z, Zhu X, Huang W, Zhao X, Liu Q, Wang B, Chen X, Wang J, Zou J.Wang Z, et al.Front Immunol. 2022 Mar 22;13:862764. doi: 10.3389/fimmu.2022.862764. eCollection 2022.Front Immunol. 2022.PMID:35392096Free PMC article.
- Global profiling of megalocytivirus-induced proteins in tongue sole (Cynoglossus semilaevis) spleen identifies cellular processes essential to viral infection.Zhang J, Sun L.Zhang J, et al.Dev Comp Immunol. 2019 Mar;92:150-159. doi: 10.1016/j.dci.2018.11.006. Epub 2018 Nov 11.Dev Comp Immunol. 2019.PMID:30428365Free PMC article.
- Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2.Chen SN, Gan Z, Hou J, Yang YC, Huang L, Huang B, Wang S, Nie P.Chen SN, et al.Nat Commun. 2022 Feb 22;13(1):999. doi: 10.1038/s41467-022-28645-6.Nat Commun. 2022.PMID:35194032Free PMC article.
- Transcription of NOD1 and NOD2 and their interaction with CARD9 and RIPK2 in IFN signaling in a perciform fish, the Chinese perch,Siniperca chuatsi.Peng XY, Wang KL, Li L, Li B, Wu XY, Zhang ZW, Li N, Liu LH, Nie P, Chen SN.Peng XY, et al.Front Immunol. 2024 Apr 23;15:1374368. doi: 10.3389/fimmu.2024.1374368. eCollection 2024.Front Immunol. 2024.PMID:38715616Free PMC article.
- Structural and Functional Characterization of a Fish Type I Subgroup d IFN Reveals Its Binding to Receptors.Guan Y, Chen J, Guan H, Chen TT, Teng Y, Wei Z, Li Z, Ouyang S, Chen X.Guan Y, et al.J Immunol. 2024 Apr 1;212(7):1207-1220. doi: 10.4049/jimmunol.2300651.J Immunol. 2024.PMID:38345351Free PMC article.
Publication types
MeSH terms
Substances
Supplementary concepts
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous