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Review
.2018 Jan 8:8:1902.
doi: 10.3389/fimmu.2017.01902. eCollection 2017.

Epstein-Barr Virus and Hemophagocytic Lymphohistiocytosis

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Review

Epstein-Barr Virus and Hemophagocytic Lymphohistiocytosis

Rebecca A Marsh. Front Immunol..

Abstract

Epstein-Barr virus (EBV) is a ubiquitous virus that infects nearly all people worldwide without serious sequela. However, for patients who have genetic diseases which predispose them to the development of hemophagocytic lymphohistiocytosis (HLH), EBV infection is a life-threatening problem. As a part of a themed collection of articles on EBV infection and human primary immune deficiencies, we will review key concepts related to the understanding and treatment of HLH.

Keywords: Epstein–Barr virus; Mononucleosis; X-linked Lymphoproliferative Disease; hemophagocytic lymphohistiocytosis; primary immunodeficiency.

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Figure 1
Figure 1
Illustration of involvement of selected primary hemophagocytic lymphohistiocytosis proteins in cytotoxic lymphocyte degranulation and target cell killing. Antibodies against markers used in selected screening diagnostics are also shown (perforin and CD107a).
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