doi: 10.1073/pnas.76.10.4827.
Structure of the human G gamma-A gamma-delta-beta-globin gene locus
- PMID:291902
- PMCID: PMC413030
- DOI: 10.1073/pnas.76.10.4827
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Structure of the human G gamma-A gamma-delta-beta-globin gene locus
R Bernards et al. Proc Natl Acad Sci U S A.1979 Oct.
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Abstract
We have constructed a physical map of the human G gamma-, A gamma-, delta-, and beta-globin genes. The previously described maps of the fetal and adult beta-like globin genes have been linked to one another by identification of a DNA fragment, generated by BamHI, that contains part of each of the A gamma- and delta-globin genes. The map obtained, which spans more than 40 kilobases, shows the following intergene distances: between G gamma and A gamma, 3500 base pairs; between A gamma and delta, 13,500 base pairs; and between delta and beta, 5500 base pairs. All genes are transcribed from the same DNA strand.
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