Semiconducting polymer-based nanoparticles with strong absorbance in NIR-II window for in vivo photothermal therapy and photoacoustic imaging

Ziyang Cao¹, Liangzhu Feng², Guobing Zhang³, Junxia Wang⁴, Song Shen⁴, Dongdong Li⁴, Xianzhu Yang⁵

Affiliations

¹ School of Biological and Medical Engineering, Hefei University of Technology, Hefei, Anhui 230009, China.
² Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
³ Academy of Opto-Electronic Technology, Hefei University of Technology, Hefei, Anhui 230009, PR China.
⁴ School of Medicine, South China University of Technology, Guangzhou, Guandong 510006, PR China.
⁵ School of Biological and Medical Engineering, Hefei University of Technology, Hefei, Anhui 230009, China; School of Medicine, South China University of Technology, Guangzhou, Guandong 510006, PR China; Institutes for Life Sciences, South China University of Technology, Guangzhou, Guandong 510006, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guandong 510006, PR China. Electronic address: yangxz@scut.edu.cn.

PMID:29175079
DOI: 10.1016/j.biomaterials.2017.11.016

Semiconducting polymer-based nanoparticles with strong absorbance in NIR-II window for in vivo photothermal therapy and photoacoustic imaging

Ziyang Cao et al. Biomaterials.2018 Feb.

.2018 Feb:155:103-111.

doi: 10.1016/j.biomaterials.2017.11.016. Epub 2017 Nov 14.

Authors

Ziyang Cao¹, Liangzhu Feng², Guobing Zhang³, Junxia Wang⁴, Song Shen⁴, Dongdong Li⁴, Xianzhu Yang⁵

Affiliations

¹ School of Biological and Medical Engineering, Hefei University of Technology, Hefei, Anhui 230009, China.
² Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
³ Academy of Opto-Electronic Technology, Hefei University of Technology, Hefei, Anhui 230009, PR China.
⁴ School of Medicine, South China University of Technology, Guangzhou, Guandong 510006, PR China.
⁵ School of Biological and Medical Engineering, Hefei University of Technology, Hefei, Anhui 230009, China; School of Medicine, South China University of Technology, Guangzhou, Guandong 510006, PR China; Institutes for Life Sciences, South China University of Technology, Guangzhou, Guandong 510006, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guandong 510006, PR China. Electronic address: yangxz@scut.edu.cn.

PMID:29175079
DOI: 10.1016/j.biomaterials.2017.11.016

Abstract

Near-infrared (NIR) light-induced photothermal therapy (PTT) has attracted much interest in recent years. In the NIR region, tissue penetration ability of the second biological near-infrared window (1000-1350 nm) is recognized to be stronger than that of the first window (650-950 nm). However, NIR light absorbers in the second NIR region (NIR-II) have been scant even though various NIR light absorbers in the first NIR region (NIR-I) have been widely explored. In this work, a thieno-isoindigo derivative-based semiconducting polymer, PBTPBF-BT, were formulated into PEGylated nanoparticles. The obtained nanoparticle NP_PBTPBF-BT exhibited strong absorption in NIR-II region, inherent high photothermal conversion efficacy, and excellent photostability. The in vitro and in vivo PTT study employing 1064 nm laser in NIR-II window revealed that NP_PBTPBF-BT could efficiently ablate tumor cell at a power density of 0.42 W/cm² (the skin tolerance threshold value). Moreover, NP_PBTPBF-BT with excellent photostability exhibited enhanced photoacoustic (PA) imaging of tumor in living mice, suggesting the great probability of using NP_PBTPBF-BT for in vivo PA imaging-guided PTT in the NIR-II window.

Keywords: Cancer therapy; Hyperthermia; Photothermal therapy; Second NIR window; Semiconducting polymer.

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Semiconducting polymer-based nanoparticles with strong absorbance in NIR-II window for in vivo photothermal therapy and photoacoustic imaging

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Semiconducting polymer-based nanoparticles with strong absorbance in NIR-II window for in vivo photothermal therapy and photoacoustic imaging

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