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Review
.2017 Oct;41(5):327-336.
doi: 10.4093/dmj.2017.41.5.327.

Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism

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Review

Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism

Muthu Periasamy et al. Diabetes Metab J.2017 Oct.

Abstract

Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-mediated uncoupling in brown adipose tissue (BAT) and white adipose tissue to increase energy expenditure to control weight gain. However, relying on UCP1-based thermogenesis alone may not be sufficient to control obesity in humans. On the other hand, skeletal muscle is the largest organ and a major contributor to basal metabolic rate and increasing energy expenditure in muscle through nonshivering thermogenic mechanisms, which can substantially affect whole body metabolism and weight gain. In this review we will describe the role of Sarcolipin-mediated uncoupling of Sarcoplasmic Reticulum Calcium ATPase (SERCA) as a potential mechanism for increased energy expenditure both during cold and diet-induced thermogenesis.

Keywords: ATP hydrolysis; Calcium cycling; Diabetes mellitus; Obesity; Sarcolipin; Sarcoplasmic reticulum calcium-transporting ATPases; Skeletal muscle thermogenesis.

Copyright © 2017 Korean Diabetes Association.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Proposed mechanism to show how sarcolipin (SLN)/sarcoendoplasmic reticulum calcium APTase (SERCA) interaction affects muscle metabolism. SERCA uses adenosine triphosphate (ATP) hydrolysis to actively transport Ca2+ from the cytosol into the sarcoplasmic reticulum lumen. SLN and Ca2+ bind competitively to SERCA during Ca2+ transport. SLN binding to SERCA does not inhibit ATP hydrolysis but prevents Ca2+ transport by a mechanism named uncoupling, where Ca2+ slips back into cytosol. Uncoupling of SERCA leads to futile cycling of the SERCA pump resulting in increased ATP hydrolysis/heat production; thus, creating energy demand. Uncoupling of SERCA increases cytosolic Ca2+ acutely, thereby promoting Ca2+ entry into mitochondria matrix activating the oxidative metabolism and ATP synthesis. RyR1, ryanodine receptor 1; ADP, adenosine diphosphate; Pi, inorganic phosphate.
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References

    1. Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell. 2001;104:531–543. - PubMed
    1. Lepor NE, Fouchia DD, McCullough PA. New vistas for the treatment of obesity: turning the tide against the leading cause of morbidity and cardiovascular mortality in the developed world. Rev Cardiovasc Med. 2013;14:20–39. - PubMed
    1. Ogden CL, Carroll MD, Lawman HG, Fryar CD, Kruszon-Moran D, Kit BK, Flegal KM. Trends in obesity prevalence among children and adolescents in the United States, 1988-1994 through 2013-2014. JAMA. 2016;315:2292–2299. - PMC - PubMed
    1. Ogden CL, Carroll MD, Fryar CD, Flegal KM. Prevalence of obesity among adults and youth: United States, 2011-2014. NCHS Data Brief. 2015;(219):1–8. - PubMed
    1. Padwal R, Li SK, Lau DC. Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int J Obes Relat Metab Disord. 2003;27:1437–1446. - PubMed

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