Comparative Study
doi: 10.1016/0888-7543(88)90148-6.Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes
Affiliations
- PMID:2906326
- DOI: 10.1016/0888-7543(88)90148-6
Item in Clipboard
Comparative Study
Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes
N C Dracopoli et al. Genomics.1988 Aug.
Display options
Format
Display options
Format
Abstract
Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), have been assigned to mouse chromosome 3 and human chromosome 1p22. We have used the techniques of linkage analysis and pulsed field gel electrophoresis to determine the proximity of these two antithetically regulated genes in this conserved linkage group. Four novel restriction fragment length polymorphisms were identified at the human TSHB gene. Two-point linkage analysis between TSHB and NGFB in 46 families, including the Centre d'Etude du Polymorphisme Humain (CEPH) reference panel, demonstrated no recombination (theta = 0.00, Z = 42.8). Analysis of this region by pulsed field gel electrophoresis showed that the genes for TSHB and NGFB are located less than 310 kb apart in man and 220 kb in the mouse.
Similar articles
- Chromosome regional mapping for the human thyroid stimulating hormone beta subunit (TSHB) gene.Tokino T, Hayashizaki Y, Takata KI, Yoshida MC, Matsubara K.Tokino T, et al.Cytogenet Cell Genet. 1990;53(2-3):140-3. doi: 10.1159/000132915.Cytogenet Cell Genet. 1990.PMID:2369842
- A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I.Dracopoli NC, Stanger BZ, Ito CY, Call KM, Lincoln SE, Lander ES, Housman DE.Dracopoli NC, et al.Am J Hum Genet. 1988 Oct;43(4):462-70.Am J Hum Genet. 1988.PMID:2902785Free PMC article.
- Assignment of the gene for the beta subunit of thyroid-stimulating hormone to the short arm of human chromosome 1.Dracopoli NC, Rettig WJ, Whitfield GK, Darlington GJ, Spengler BA, Biedler JL, Old LJ, Kourides IA.Dracopoli NC, et al.Proc Natl Acad Sci U S A. 1986 Mar;83(6):1822-6. doi: 10.1073/pnas.83.6.1822.Proc Natl Acad Sci U S A. 1986.PMID:3006075Free PMC article.
- The use of linkage analysis and the Centre d'Etude Polymorphisme Humain (CEPH) panel of DNA in the study of the arginine vasopressin, oxytocin and prodynorphin gene loci.Summar ML.Summar ML.Prog Brain Res. 1992;93:309-17. doi: 10.1016/s0079-6123(08)64581-1.Prog Brain Res. 1992.PMID:1362280Review.No abstract available.
- [Structure and regulation of human thyroid-stimulating hormone (TSH) gene].Miyoshi I, Kasai N, Hayashizaki Y.Miyoshi I, et al.Nihon Rinsho. 1994 Apr;52(4):940-7.Nihon Rinsho. 1994.PMID:8196184Review.Japanese.
Cited by
- Regional chromosomal assignment of human 3-beta-hydroxy-5-ene steroid dehydrogenase to 1p13.1 by non-isotopic in situ hybridisation.Morrison N, Nickson DA, McBride MW, Mueller UW, Boyd E, Sutcliffe RG.Morrison N, et al.Hum Genet. 1991 Jun;87(2):223-5. doi: 10.1007/BF00204189.Hum Genet. 1991.PMID:2066113No abstract available.
- Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression.Dracopoli NC, Harnett P, Bale SJ, Stanger BZ, Tucker MA, Housman DE, Kefford RF.Dracopoli NC, et al.Proc Natl Acad Sci U S A. 1989 Jun;86(12):4614-8. doi: 10.1073/pnas.86.12.4614.Proc Natl Acad Sci U S A. 1989.PMID:2734311Free PMC article.
- Familial hypothyroidism caused by a nonsense mutation in the thyroid-stimulating hormone beta-subunit gene.Dacou-Voutetakis C, Feltquate DM, Drakopoulou M, Kourides IA, Dracopoli NC.Dacou-Voutetakis C, et al.Am J Hum Genet. 1990 May;46(5):988-93.Am J Hum Genet. 1990.PMID:1971148Free PMC article.
- A linkage map of mouse chromosome 1 using an interspecific cross segregating for the gld autoimmunity mutation.Watson ML, D'Eustachio P, Mock BA, Steinberg AD, Morse HC 3rd, Oakey RJ, Howard TA, Rochelle JM, Seldin MF.Watson ML, et al.Mamm Genome. 1992;2(3):158-71. doi: 10.1007/BF00302874.Mamm Genome. 1992.PMID:1543910
- Mouse chromosome 3.Meisler MH, Todd JA, Rodrigues N, Wakeland EK, Seldin MF.Meisler MH, et al.Mamm Genome. 1992;3 Spec No:S44-54. doi: 10.1007/BF00648421.Mamm Genome. 1992.PMID:1498442Review.No abstract available.
Publication types
MeSH terms
Substances
Related information
Grants and funding
etc
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
Research Materials
Miscellaneous