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Clinical Trial
.1988;34(1):109-12.
doi: 10.1007/BF01061430.

Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans

Affiliations
Clinical Trial

Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans

S R Bareggi et al. Eur J Clin Pharmacol.1988.

Abstract

Six healthy, fasting volunteers were given single doses of chlordesmethyldiazepam by 1 mg i.v., or as drops or tablets. Chlordesmethyldiazepam and its metabolite, lorazepam, in multiple plasma samples and in urine collected for 120 h after each dose were determined by electron-capture GLC. Mean kinetic variables for intravenous chlordesmethyldiazepam were: volume of distribution, 1.71 l.kg-1; elimination half-life, 113 h; total clearance, 0.21 ml.min-1.kg-1; cumulative excretion of lorazepam glucuronide 24.2% of the dose. Following a lag time of 15.5 min (tablets) and 4.2 min (drops), which were significantly different, the absorption of oral chlordesmethyldiazepam was a first order process, with apparent absorption half-life values averaging 1.5 h (tablets) and 1.1 h (drops). Bioavailability was 77% for tablets and 79% for drops.

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References

    1. J Med Chem. 1979 Apr;22(4):436-40 - PubMed
    1. J Chromatogr. 1979 Jan 11;168(1):260-5 - PubMed
    1. Eur J Drug Metab Pharmacokinet. 1986 Jul-Sep;11(3):171-4 - PubMed
    1. Clin Pharmacokinet. 1978 Jan-Feb;3(1):72-91 - PubMed
    1. Eur J Clin Pharmacol. 1977;11(5):345-9 - PubMed

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